Results 81 to 90 of about 15,343 (151)

Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents [version 1; referees: 4 approved]

F1000Research, 2017
Although significant levels of side effects are often associated with their use, microtubule-directed agents that primarily target fast-growing mitotic cells have been considered to be some of the most effective anti-cancer therapeutics. With the hope of
Jung-Eun Park, David Hymel, Terrence R. Burke, Jr., Kyung S. Lee   +3 more
doaj   +1 more source

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

Molecular Microbiology, Volume 125, Issue 6, Page 475-492, June 2026.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark, Michelle King, Angela E. M. Ibler, Salma Srour, Francesca Brown, James Sheffield, Nadia Baseer, Ellen G. Vernon, Yifeng Zhang, Christopher Staples, Lilliana Radoshevich, Daniel Humphreys   +11 more
wiley   +1 more source

Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization

Cell Division, 2019
Background A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIγ), a ...
Tz-Chi Lin, Hsiao-Hui Kuo, Yi-Chen Wu, Tiffany S. Pan, Ling-Huei Yih   +4 more
doaj   +1 more source

Polo-like kinase 4 phosphorylates Chk2 [PDF]

Cell Cycle, 2009
Steve, Petrinac, Melissa L, Ganuelas, Sepal, Bonni, Jordan, Nantais, John W, Hudson   +4 more
openaire   +2 more sources

Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies. [PDF]

Cancers (Basel), 2023
Kim Y, Hwang JY, Kim DK, Na K, Lee S, Baek S, Kang SS, Yang SM, Kim MH, Han H, Lee CY, Han YJ, Hong MH, Lee JB, Lim SM, Cho BC, Park Y, Pyo KH.   +17 more
europepmc   +1 more source

Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly. [PDF]

Mol Biol Cell, 2023
Ryniawec JM, Buster DW, Slevin LK, Boese CJ, Amoiroglou A, Dean SM, Slep KC, Rogers GC.   +7 more
europepmc   +1 more source

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Nature Communications
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised.
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett   +14 more
doaj   +1 more source

The regulation of polo-like kinase 4 in centrosome duplication

Centrosomes are important cell organelles that serve as main microtubule-organizing centers and are involved in diverse cellular processes, most importantly cell division by facilitating formation of the bipolar spindle in mitosis. Each centrosome consists of a pair of centrioles, which is duplicated exactly once per cell cycle.
openaire   +1 more source

Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation

Respiratory Research
Background Galactose lectin-3 (Gal-3) has been shown to promote the progression of pulmonary arterial hypertension (PAH), yet the intricate molecular mechanisms are still unclear.
Jia Zhang, Jin Liu, Yuqian Chen, Huan Chen, Yihan Meng, Yan Wang, Yuanjie Qiu, Huizhong Hu, Wenhua Shi, Manxiang Li   +9 more
doaj   +1 more source

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.

PLoS ONE, 2015
ObjectiveIn this study, the anticancer mechanisms of MT-4 were examined in A2780 and multidrug-resistant NCI-ADR/res human ovarian cancer cell lines.MethodsTo evaluate the activity of MT-4, we performed in vitro cell viability and cell cycle assays and ...
Hui Chen Pai, Sunil Kumar, Chien-Chang Shen, Jing Ping Liou, Shiow Lin Pan, Che Ming Teng   +5 more
doaj   +1 more source