Results 81 to 90 of about 17,357,527 (148)

Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis

Poultry Science
: The circadian clock is crucial for maintaining lipid metabolism homeostasis in mammals. Despite the economic importance of fat content in poultry, research on the regulatory effects and molecular mechanisms of the circadian clock on avian hepatic lipid
Panlin Wang, Fang Li, Yanyan Sun, Yunlei Li, Xiuyu Xie, Xue Du, Lu Liu, Yongshu Wu, Dan Song, Hui Xiong, Jilan Chen, Xiangchen Li   +11 more
doaj   +1 more source

Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents [version 1; referees: 4 approved]

F1000Research, 2017
Although significant levels of side effects are often associated with their use, microtubule-directed agents that primarily target fast-growing mitotic cells have been considered to be some of the most effective anti-cancer therapeutics. With the hope of
Jung-Eun Park, David Hymel, Terrence R. Burke, Jr., Kyung S. Lee   +3 more
doaj   +1 more source

Milia en plaque – therapeutic response to calcipotriol

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Veronika Hall, Johannes M. Weiss
wiley   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Polo-like Kinase 1 Inhibition in KRAS-Mutated Metastatic Colorectal Cancer

Summary: Inhibition of Polo-like kinase 1 (Plk1) is a promising new target and therapeutic strategy in metastatic colorectal cancer, especially those with KRAS mutations.
Justin Stebbing (181883), Andrea J Bullock (18864034)   +1 more
core   +5 more sources

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells [PDF]

, 2013
This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Caron, HN, Allen, M. (Matthew), Hartsink-Segers, Stefanie A., Horstmann, Martin, Horstmann, M.A. (Martin), Boer, M.L. (Monique) den, Allen, Matthew, Horstmann, M, Clifford, Steven C., Caron, Huib N., Exalto, C. (Carla), Caron, H.N. (Huib), Clifford, SC, Williamson, Daniel, den Boer, Monique L., Pieters, Rob, Hartsink-Segers, S.A. (S.), Williamson, D, Clifford, S.C. (Steven), den Boer, Monique, Exalto, Carla, Allen, M, Segers, Stefanie, Williamson, D. (Daniel), Pieters, R. (Rob)   +24 more
core   +1 more source

Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization

Cell Division, 2019
Background A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIγ), a ...
Tz-Chi Lin, Hsiao-Hui Kuo, Yi-Chen Wu, Tiffany S. Pan, Ling-Huei Yih   +4 more
doaj   +1 more source

SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS [PDF]

, 2020
Targeted therapies are crucial for personalizing cancer treatment, but tumour heterogeneity presents a challenge in the identification of effective targets.
Cunningham, Chelsea E
core  

Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts [PDF]

, 2010
The integrity of DNA replication control and checkpoint mechanisms is essential for preventing tumorigenesis. DNA replication is initiated by the S-CDK and DDK kinases which mediate the unwinding of the replication fork.
Gold, Daniel A.
core   +1 more source

On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]

, 2015
The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
core   +1 more source