Results 271 to 280 of about 203,778 (305)

Poly(A), poly(A) binding protein and the regulation of mRNA stability

Trends in Biochemical Sciences, 1989
This review has focused on the possibility that interactions between mRNA sequences and the poly(A)-nucleoprotein complex play important roles in mRNA turnover. It is important to stress that additional genetic and biochemical tests are necessary to characterize how PABP interacts with mRNA in cells and to determine whether the poly(A) protection ...
P, Bernstein, J, Ross
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Translational Control of Poly(A)‐Binding Protein Expression

European Journal of Biochemistry, 1996
Poly(A)‐binding protein (PABP) is important for translation of eukaryotic mRNA and may be involved in shortening of its poly(A) tract. In many eukaryotic cells, this mRNA is inefficiently translated. The 5′ untranslated region (UTR) of PABP mRNA has several adenine‐rich regions which may serve as the PABP‐binding sites to control its translation by a ...
J, Bag, J, Wu
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Poly(A)-binding protein (PABP): a common viral target

Biochemical Journal, 2010
Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization.
Richard W P, Smith, Nicola K, Gray
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Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

Nature, 1979
THE polysomal mRNA of eukaryotes is associated with at least two tightly binding proteins of approximate molecular weights 75,000 and 60,0001–5. The 75,000 MW polypeptide (P75) is specifically bound to the poly(A) portion of the mRNA2,6,7. Heterogeneous nuclear RNA molecules (HnRNAs), which apparently contain the precursors to the cytoplasmic mRNAs ...
K M, Rose, S T, Jacob, A, Kumar
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Conformational Properties of Poly(A)-Binding Protein Complexed with Poly(A) RNA

The Journal of Physical Chemistry B
Microscopic understanding of protein-RNA interactions is important for different biological activities, such as RNA transport, translation, splicing, silencing, etc. Polyadenine (Poly(A)) binding proteins (PABPs) make up a class of regulatory proteins that play critical roles in protecting the poly(A) tails of cellular mRNAs from nuclease degradation ...
Arun Chakrabortty, Sandip Mondal, Sanjoy Bandyopadhyay   +2 more
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Trypanosoma brucei:Identification and Purification of a Poly(A)-Binding Protein

Experimental Parasitology, 1998
Abstract Pitula, J., Ruyechan, W. T., and Williams, N. 1998. Trypanosoma brucei: Identification and purification of a poly(A)-binding protein. Experimental Parasitology 88 , 157–160.
J, Pitula, W T, Ruyechan, N, Williams
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Interaction of anti‐proliferative protein Tob with poly(A)‐binding protein and inducible poly(A)‐binding protein: implication of Tob in translational control

Genes to Cells, 2005
Tob is a member of an emerging family of anti‐proliferative proteins that suppress cell growth when over‐expressed. tob mRNA is highly expressed in anergic T cells and over‐expression of Tob suppresses transcription of interleukin‐2 (IL‐2) through its interaction with Smads.
Kentaro, Okochi, Toru, Suzuki, Jun-ichiro, Inoue, Satoru, Matsuda, Tadashi, Yamamoto   +4 more
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Molecular Characterization of Poly(A)-binding Protein from Daucus carota

DNA Sequence, 2003
Poly(A)-binding proteins (PABs) bind to the poly(A) tails of most eukaryotic mRNAs and thereby influence the translational efficiency as well as the stability of the mRNAs thus bound. Compared with the data on yeast PAB, relatively little is known about the functions of PABs in higher plants.
Hui-Xin, Lin, Lei, Zhang, Zhi-Pan, Yang, Mei-Juan, Huang, Nai-Hu, Wu   +4 more
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mRNA-specific regulation of translation by poly(A)-binding proteins

Biochemical Society Transactions, 2010
The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of disease. Numerous studies have highlighted the diverse, and sometimes related, mechanisms which underlie the regulation of global translation rates and the translational control of specific mRNAs ...
Hannah M, Burgess, Nicola K, Gray
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Poly(A)-binding proteins: Structure, domain organization, and activity regulation

Biochemistry (Moscow), 2013
RNA-binding proteins are of vital importance for mRNA functioning. Among these, poly(A)-binding proteins (PABPs) are of special interest due to their participation in virtually all mRNA-dependent events that is caused by their high affinity for A-rich mRNA sequences.
I A, Eliseeva, D N, Lyabin, L P, Ovchinnikov   +2 more
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