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Structure and function of poly(A) binding proteins
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 2004Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay.
Uwe Kuhn, Elmar Wahle
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Poly(A), poly(A) binding protein and the regulation of mRNA stability
Trends in Biochemical Sciences, 1989This review has focused on the possibility that interactions between mRNA sequences and the poly(A)-nucleoprotein complex play important roles in mRNA turnover. It is important to stress that additional genetic and biochemical tests are necessary to characterize how PABP interacts with mRNA in cells and to determine whether the poly(A) protection ...
P, Bernstein, J, Ross
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Translational Control of Poly(A)‐Binding Protein Expression
European Journal of Biochemistry, 1996Poly(A)‐binding protein (PABP) is important for translation of eukaryotic mRNA and may be involved in shortening of its poly(A) tract. In many eukaryotic cells, this mRNA is inefficiently translated. The 5′ untranslated region (UTR) of PABP mRNA has several adenine‐rich regions which may serve as the PABP‐binding sites to control its translation by a ...
J, Bag, J, Wu
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Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related
Nature, 1979THE polysomal mRNA of eukaryotes is associated with at least two tightly binding proteins of approximate molecular weights 75,000 and 60,0001–5. The 75,000 MW polypeptide (P75) is specifically bound to the poly(A) portion of the mRNA2,6,7. Heterogeneous nuclear RNA molecules (HnRNAs), which apparently contain the precursors to the cytoplasmic mRNAs ...
K M, Rose, S T, Jacob, A, Kumar
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Conformational Properties of Poly(A)-Binding Protein Complexed with Poly(A) RNA
The Journal of Physical Chemistry BMicroscopic understanding of protein-RNA interactions is important for different biological activities, such as RNA transport, translation, splicing, silencing, etc. Polyadenine (Poly(A)) binding proteins (PABPs) make up a class of regulatory proteins that play critical roles in protecting the poly(A) tails of cellular mRNAs from nuclease degradation ...
Arun Chakrabortty +2 more
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Trypanosoma brucei:Identification and Purification of a Poly(A)-Binding Protein
Experimental Parasitology, 1998Abstract Pitula, J., Ruyechan, W. T., and Williams, N. 1998. Trypanosoma brucei: Identification and purification of a poly(A)-binding protein. Experimental Parasitology 88 , 157–160.
J, Pitula, W T, Ruyechan, N, Williams
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Genes to Cells, 2005
Tob is a member of an emerging family of anti‐proliferative proteins that suppress cell growth when over‐expressed. tob mRNA is highly expressed in anergic T cells and over‐expression of Tob suppresses transcription of interleukin‐2 (IL‐2) through its interaction with Smads.
Kentaro, Okochi +4 more
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Tob is a member of an emerging family of anti‐proliferative proteins that suppress cell growth when over‐expressed. tob mRNA is highly expressed in anergic T cells and over‐expression of Tob suppresses transcription of interleukin‐2 (IL‐2) through its interaction with Smads.
Kentaro, Okochi +4 more
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Biochemistry, 2002
The nuclear poly(A) binding protein (PABPN1) binds the growing poly(A) tail during pre-mRNA 3'-end processing, stimulating its elongation and controlling its final length. Here we report binding studies of PABPN1 to poly(A) in solution. Quantitative fluorescence titration was used to determine the stoichiometry, intrinsic affinity, and cooperativity of
Sylke, Meyer +2 more
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The nuclear poly(A) binding protein (PABPN1) binds the growing poly(A) tail during pre-mRNA 3'-end processing, stimulating its elongation and controlling its final length. Here we report binding studies of PABPN1 to poly(A) in solution. Quantitative fluorescence titration was used to determine the stoichiometry, intrinsic affinity, and cooperativity of
Sylke, Meyer +2 more
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Poly(A)-binding protein (PABP): a common viral target
Biochemical Journal, 2010Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization.
Richard W P, Smith, Nicola K, Gray
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