Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase. [PDF]
PLoS ONE, 2017 Ccr4 is a major cytoplasmic deadenylase involved in mRNA poly(A) tail shortening in Saccharomyces cerevisiae. We have previously shown that Ccr4 negatively regulates expression of LRG1 mRNA encoding a GTPase-activating protein for the small GTPase Rho1 ...
Duong Long Duy +2 more
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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. [PDF]
PLoS Genetics, 2015 The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression.
Christian Kappel +9 more
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Poly(A) tail regulation in stem cells and early development [PDF]
Cell RegenerationEukaryotic mRNAs are polyadenylated at their 3’-ends, and the poly(A) tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation.
Xiaosu Miao, Guang Hu
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The Dynamic Poly(A) Tail Acts as a Signal Hub in mRNA Metabolism [PDF]
Cells, 2023 In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies have suggested that polyadenylate tail may play a vital role in such a system.
Guiying Zhang +4 more
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Preserving the Poly(A) Tail: Strategies Viruses Use to ‘CYA’ (Cover Your A’s) [PDF]
VirusesThe poly(A) tail on viral mRNAs plays an important role in gene expression, given the role of the 3′ mRNA tail in mRNA stability and translation. Viruses have developed several strategies to maintain the integrity of their poly(A) tails.
Jeffrey Wilusz
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Loop structure in poly(A) tail of mRNA vaccine enhances antigen translation efficiency and mRNA stability [PDF]
npj VaccinesAs mRNA technology emerges as a groundbreaking innovation, an increasing number of studies are attempting to increase expression levels by optimizing the structure of mRNA, such as the 5’ or 3’ untranslated regions (UTR).
Ayoung Oh +18 more
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Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails [PDF]
eLife, 2020 La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al ...
Sandy Mattijssen +4 more
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RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response [PDF]
eLife, 2015 In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka +4 more
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MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA [PDF]
Nature CommunicationsThe mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating ...
Jing Yang +8 more
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PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility [PDF]
Nature CommunicationsIn oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length. Here, we introduce PAL-AI, an integrated neural network machine-learning model that accurately predicts tail-length changes in maturing
Kehui Xiang, David P. Bartel
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