Regulation of coronaviral poly(A) tail length during infection. [PDF]
PLoS ONE, 2013 The positive-strand coronavirus genome of ~30 kilobase in length and subgenomic (sg) mRNAs of shorter lengths, are 5' and 3'-co-terminal by virtue of a common 5'-capped leader and a common 3'-polyadenylated untranslated region.
Hung-Yi Wu +3 more
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The molecular basis of coupling between poly(A)-tail length and translational efficiency [PDF]
eLife, 2021 In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears.
Kehui Xiang, David P Bartel
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Impact of poly(A)-tail G-content on Arabidopsis PAB binding and their role in enhancing translational efficiency [PDF]
Genome Biology, 2019 Background Polyadenylation plays a key role in producing mature mRNAs in eukaryotes. It is widely believed that the poly(A)-binding proteins (PABs) uniformly bind to poly(A)-tailed mRNAs, regulating their stability and translational efficiency.
Taolan Zhao +11 more
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Poly (A) tail length of human mitochondrial mRNAs is tissue-specific and a mutation in LRPPRC results in transcript-specific patterns of deadenylation [PDF]
Molecular Genetics and Metabolism Reports, 2020 Mutations in LRPPRC cause Leigh Syndrome French Canadian (LSFC), an early onset neurodegenerative disease, with differential tissue involvement. The molecular basis for tissue specificity in this disease remains unknown.
Shamisa Honarmand, Eric A. Shoubridge
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Measuring the tail: Methods for poly(A) tail profiling. [PDF]
Wiley Interdiscip Rev RNA, 2023 AbstractThe 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that affects mRNA fate and translation efficiency. Polyadenylation is a posttranscriptional process that occurs in the nucleus by canonical poly(A) polymerases (PAPs).
Brouze A +3 more
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Poly(A) tail dynamics: Measuring polyadenylation, deadenylation and poly(A) tail length. [PDF]
Methods Enzymol, 2021 Transcription of mRNAs culminates in RNA cleavage and a coordinated polyadenylation event at the 3' end. In its journey to be translated, the resulting transcript is under constant regulation by cap-binding proteins, miRNAs, and RNA binding proteins, including poly(A) binding proteins (PABPs).
Murphy MR, Doymaz A, Kleiman FE.
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Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail [PDF]
Scientific Reports, 2018 Eukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins.
Ryoichi Sawazaki +8 more
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A Synthetic Poly(A) Tail Targeting Extracellular CIRP Inhibits Sepsis. [PDF]
J Immunol, 2023 Abstract Sepsis is an infectious inflammatory disease that often results in acute lung injury (ALI). Cold-inducible RNA-binding protein (CIRP) is an intracellular RNA chaperon that binds to mRNA’s poly(A) tail. However, CIRP can be released in sepsis, and extracellular CIRP (eCIRP) is a damage-associated molecular pattern, exaggerating ...
Murao A +5 more
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Dynamic RNA 3′ Uridylation and Guanylation during Mitosis
iScience, 2020 Summary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation.
Yusheng Liu, Hu Nie, Falong Lu
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RNA polyadenylation sites on the genomes of microorganisms, animals, and plants. [PDF]
PLoS ONE, 2013 Pre-messenger RNA (mRNA) 3'-end cleavage and subsequent polyadenylation strongly regulate gene expression. In comparison with the upstream or downstream motifs, relatively little is known about the feature differences of polyadenylation [poly(A)] sites ...
Xiu-Qing Li, Donglei Du
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