Results 41 to 50 of about 283,934 (290)
CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation
Scientific Reports, 2018 In many cell types, the length of the poly(A) tail of an mRNA is closely linked to its fate - a long tail is associated with active translation, a short tail with silencing and degradation. During mammalian oocyte development, two contrasting patterns of
Karl-Frédéric Vieux, Hugh J. Clarke
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eLife, 2016 Because maturing oocytes and early embryos lack appreciable transcription, posttranscriptional regulatory processes control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout ...
Stephen W Eichhorn +5 more
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Poly(a) selection introduces bias and undue noise in direct RNA-sequencing
BMC Genomics, 2022 Background Genome-wide RNA-sequencing technologies are increasingly critical to a wide variety of diagnostic and research applications. RNA-seq users often first enrich for mRNA, with the most popular enrichment method being poly(A) selection.
Marcus J. Viscardi, Joshua A. Arribere
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FEBS Open Bio, 2022 The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases ...
Rafailia A. A. Beta +7 more
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Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. [PDF]
PLoS ONE, 2014 Maternal effect genes code for oocyte proteins that are important for early embryogenesis. Transcription in oocytes does not take place from the onset of meiotic progression until zygotic genome activation.
Debora Dankert +7 more
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Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase
, 2019 The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Conti, E. +6 more
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Virology, 2014 Here we show that Tobacco mosaic virus (TMV), a positive-strand RNA virus known to end with 3׳ tRNA-like structures, does possess a small fraction of gRNA bearing polyadenylate tails. Particularly, many tails are at sites corresponding to the 3׳ end of near full length gRNA, and are composed of poly(A)-rich sequences containing the other nucleotides in
Li, Weimin +5 more
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Polyethers for biomedical applications. Polymerization of propylene oxide by organozinc/organotin catalysts [PDF]
, 1987 The polymerization of propylene oxide to obtain a high-molecular-weight polymer with an atactic structure required for the application as artificial blood vessels was investigated using combinations of organozinc and organotin compounds as catalyst.
Bantjes, Adriaan +3 more
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Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]
, 2019 Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie +5 more
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Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice
Nature Communications, 2023 In mammals, the production of mature oocytes necessitates rigorous regulation of the discontinuous meiotic cell-cycle progression at both the transcriptional and post-transcriptional levels. However, the factors underlying this sophisticated but explicit
Xue Jiang +14 more
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