Results 101 to 110 of about 18,215 (242)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 2, Page 369-388, February 2026.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Ferrichrome identified from induces apoptosis through its iron-binding site in gastric cancer cells

Tumor Biology, 2017
Ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from Lactobacillus casei ATCC334 ( L. casei ). In the present study, we investigated the effects of ferrichrome in gastric cancer cells. Cell
Masami Ijiri, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Toshikatsu Okumura   +9 more
doaj   +1 more source

Remote delivery of cancer genetic testing in veterans with metastatic prostate cancer: A Million Veteran Program pilot study

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%–12%. Methods This prospective study enrolled veterans
Bruce Montgomery, Julie A. Lynch, Jessica Brown, Kara N. Maxwell, Craig C. Teerlink, Nismeta Kabilovic, Katie Stoll, Julie Simon, Maria Kogan, Sajida Hassan, Stacey B. Whitbourne, Sumitra Muralidhar, Martin W. Schoen, Rachel Ramoni, J. Michael Gaziano, Alexandra O. Sokolova, Heather H. Cheng, Ruth Etzioni, Colin C. Pritchard   +18 more
wiley   +1 more source

Poly(Adenosine Diphosphate Ribose) Synthesis during Herpes Simplex Virus Infection

Intervirology, 1979
Immediately after infection of baby hamster kidney cells with herpes simplex virus (HSV), cellular DNA synthesis was blocked, while extensive HSV DNA synthesis began. These dramatic alterations of the control mechanisms for these two DNA synthesizing systems were not accompanied by a change in the poly(adenosine diphosphate ribose) polymerase activity.
W E, Müller, D, Falke, R K, Zahn, J, Arendes   +3 more
openaire   +2 more sources

Poly(ADP-ribose) Polymerase-1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Potential [PDF]

, 2014
Poly(ADP-ribosyl)ation reactions, carried out by poly(ADP-ribose) polymerases (PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous cellular processes (e.g., DNA repair, transcription, metabolism, or immune functions). PARP1
Bay, Péter, Little, P., Liu, P., Xu, S.
core   +1 more source

Progress in targeted therapy for breast cancer

Chronic Diseases and Translational Medicine, 2018
Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade.
Jie Ju, An-Jie Zhu, Peng Yuan
doaj   +1 more source

PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?

Medicines, 2020
Poly adenosine diphosphate-ribose polymerase inhibitors (PARPi) represent an effective therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA damage repair (DDR) genes.
Angela Dalia Ricci, Alessandro Rizzo, Chiara Bonucci, Nastassja Tober, Andrea Palloni, Veronica Mollica, Ilaria Maggio, Marzia Deserti, Simona Tavolari, Giovanni Brandi   +9 more
doaj   +1 more source

Lexicon for Clonal Hematopoiesis in Liquid Biopsy

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Historically, clonal hematopoiesis (CH) has been recognized as a confounder of cell‐free DNA (cfDNA) testing. Recent evidence now demonstrates the role of CH as a risk factor in health, generating distinct sources of cfDNA that can be leveraged for liquid biopsy diagnostics.
Robert Tell, Ahmet Zehir, Andrew T. Anfora, Gargi Basu, Michelle Beidelschies, Carolyn Compton, Stephen Cristiano, James H. Godsey, John Hu, Donald J. Johann, Marisa Juntilla, Rina Kansal, Christine Lo, Dorys Lopez Ramos, Vaidhyanathan Mahaganapathy, David Merriam, Christian Rolfo, Hugh Russell, Usha Singh, Daniel Stetson, Martin You, Lauren C. Leiman   +21 more
wiley   +1 more source

Specific inhibition of the differentiation of Trypanosoma cruzi [PDF]

, 2004
The morphological transformation of Trypanosoma cruzi amastigotes was studied in both mammalian cells and an extracellular differentiation system. Inhibitors of ADP-ribosyl transferase were found to block differentiation in both cases, without affecting ...
Williams, GT
core   +1 more source

Computational Simulation of the Bioactivity of Selected Compounds Derived From the Sapium and Salvias Genera as Anticancer Agents

BioMed Research International, Volume 2026, Issue 1, 2026.
The investigation into the anticancer properties of plant extracts, which are known to be effective therapeutic agents with minimal side effects, is gaining significant traction. The current study examined the bioactive compounds extracted from Sapium ellipticum and Salvia miltiorrhiza Bunge.
Russell B. O. Ouma, Usama Raza, Silas M. Ngari, Joshua K. Kibet, Uzair Nisar, Muhammad Waqar Ali, Baisakhi Banerjee   +6 more
wiley   +1 more source