Results 111 to 120 of about 18,215 (242)
Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells
Tumor Biology, 2017 Cell adhesion–mediated drug resistance is an important factor that influences the effects of chemotherapy in multiple myeloma. DTX3L, a ubiquitin ligase, plays a key role in cell-cycle-related process.
Yaodong Shen +3 more
doaj +1 more source
Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line [PDF]
, 2003 ObjectiveTo explore inhibition effects of veliparib as PARP inhibitor combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.MethodsBEL-7404 was taken as the object of study and conventional culture was performed.
Yu +17 more
core +1 more source
CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factors contributing to disease development.
Alessandro Mannucci, Ajay Goel
wiley +1 more source
Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region [PDF]
Middle East Journal of CancerApproximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HER2)-negative, but demonstrating low HER2 expression, are now being defined as a new HER2-low subset or HER2-low category of BC.
Shaheenah Dawood +9 more
doaj +1 more source
Journal of Biological Chemistry, 1968 An enzyme associated with mammalian chromatin catalyzed the transfer of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide to histone with the simultaneous release of nicotinamide. A successive transfer of the ADP-ribose moiety resulted in the formation and elongation of a homopolymer with repeating ADP-ribose units ...
Y, Nishizuka +3 more
openaire +2 more sources
A systematic analysis of the PARP protein family identifies new functions critical for cell physiology [PDF]
, 2013 The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD[superscript +] as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological conditions is unknown.
Chang, Paul +4 more
core +1 more source
DNA methylation and chromatin structure: The puzzling CpG islands [PDF]
, 2005 DNA methylation is the epigenetic modification,which introduces 5mC as fifth base onto DNA. As for the distribution of 5rnCs, it is well known that they distribute themselves in a non-random fashion in genomic DNA so that methylation pattern is ...
CAIAFA, Paola, ZAMPIERI, Michele
core +1 more source
Exploring NAD(+) metabolism in host-pathogen interactions [PDF]
, 2016 Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana +3 more
core +1 more source
Perinatal asphyxia: CNS development and deficits with delayed onset [PDF]
, 2014 Perinatal asphyxia constitutes a prototype of obstetric complications occurring when pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of the period lacking oxygenation, leading to death if not re-established ...
Bustamante, D +12 more
core +1 more source
Cell Reports MedicineSummary: Preclinical studies suggest synergistic effects between androgen receptor inhibitors and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors.
Tingwei Zhang +12 more
doaj +1 more source