Results 111 to 120 of about 18,599 (272)
The contemporary management of prostate cancer
CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 552-586, November/December 2025.Abstract Prostate cancer is the most common cancer in two thirds of the world, with an expected doubling in both incidence and mortality in the next two decades. No strong environmental associations exist for the development of prostate cancer; therefore, lifestyle measures are unlikely to mitigate this increasing burden.
Deep Chakrabarti +11 more
wiley +1 more source
Adjuvant Chemotherapy in Lymph Node‐Negative, T1 Triple‐Negative Breast Cancer
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background The role of adjuvant chemotherapy in small, node‐negative triple‐negative breast cancer (TNBC) has not been formally assessed in clinical trials. We aimed to evaluate the benefit of adjuvant chemotherapy in this population. Methods This is a retrospective study using the National Cancer Database (NCDB).
Jesus D. Anampa +4 more
wiley +1 more source
Triple negative breast cancer: new perspectives for targeted therapies [PDF]
, 2015 Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide +8 more
core +1 more source
Progress in targeted therapy for breast cancer
Chronic Diseases and Translational Medicine, 2018 Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade.
Jie Ju, An-Jie Zhu, Peng Yuan
doaj +1 more source
PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?
Medicines, 2020 Poly adenosine diphosphate-ribose polymerase inhibitors (PARPi) represent an effective therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA damage repair (DDR) genes.
Angela Dalia Ricci +9 more
doaj +1 more source
Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation [PDF]
, 2009 Poly(ADP-ribosyl)ation of the conserved multifunctional transcription factor CTCF was previously identified as important to maintain CTCF insulator and chromatin barrier functions.
Chernukhin, Igor +8 more
core +2 more sources
Immunity, Inflammation and Disease, Volume 13, Issue 11, November 2025.ABSTRACT Background Annexin A1 (ANXA1), a calcium‐dependent phospholipid‐binding protein, plays a critical role in regulating inflammation, apoptosis, immune responses, and vascular remodeling. It is increasingly recognized for its potential as a therapeutic target and diagnostic biomarker in various circulatory diseases, including sepsis, hypertension,
Qiuyu Dai +4 more
wiley +1 more source
Interaction of Nucleosides and Related Compounds with Nucleic Acids as Indicated by the Change of Helix-Coil Transition Temperature [PDF]
, 1962 A series of compounds has been tested for effectiveness in lowering the melting temperature of poly A and of thymus DNA. The order of increasing activity was found to be: adonitol, methyl riboside (both negligible) < cyclohexanol < phenol, pyrimidine ...
Helmkamp, G. K. +2 more
core +1 more source
The Mechanism and Potential Therapeutic Strategies of Vascular Aging
AGING MEDICINE, Volume 8, Issue 5, Page 475-492, October 2025.The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu +4 more
wiley +1 more source
Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells
Tumor Biology, 2017 Cell adhesion–mediated drug resistance is an important factor that influences the effects of chemotherapy in multiple myeloma. DTX3L, a ubiquitin ligase, plays a key role in cell-cycle-related process.
Yaodong Shen +3 more
doaj +1 more source