Results 121 to 130 of about 18,599 (272)

Nutmeg Beyond Spice: A Review on Its Therapeutic Potential, Safety and Industrial Promise

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review highlights the current findings on the pharmacological potential of M. fragrans, focusing on its health benefits and applications. M. fragrans contains alkaloids, terpenoids, phenols, flavonoids and glycosides; with myristicin, macelignan, safrole and sabinene as prime bioactive components.
Duaa Tariq, Muhammad Tauseef Sultan, Ahmad Mujtaba Noman, Hassan Raza, Shazia Akram, Hagar M. Mohamed, Muhammad Atif Khan, Muhammad Imran, Muzzamal Hussain, Anjuman Gul Memon, Muhammad Atif, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Entessar Al Jbawi   +13 more
wiley   +1 more source

Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region [PDF]

Middle East Journal of Cancer
Approximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HER2)-negative, but demonstrating low HER2 expression, are now being defined as a new HER2-low subset or HER2-low category of BC.
Shaheenah Dawood, Mohsen Mokhtar, Ahmed Alwbari, Bernardo Rapoport, Ece Esin, Hassan Jaafar, Jamal Zekri, Narjiss Berrada, Ozgur Ozyilkan, Nagi El Saghir   +9 more
doaj   +1 more source

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology [PDF]

, 2013
The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD[superscript +] as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological conditions is unknown.
Chang, Paul, Chesarone-Cataldo, Melissa, Huang, Yun-Han, Todorova, Tanya, Vyas, Sejal   +4 more
core   +1 more source

Enzymic Adenosine Diphosphate Ribosylation of Histone and Poly Adenosine Diphosphate Ribose Synthesis in Rat Liver Nuclei

Journal of Biological Chemistry, 1968
An enzyme associated with mammalian chromatin catalyzed the transfer of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide to histone with the simultaneous release of nicotinamide. A successive transfer of the ADP-ribose moiety resulted in the formation and elongation of a homopolymer with repeating ADP-ribose units ...
Y, Nishizuka, K, Ueda, T, Honjo, O, Hayaishi   +3 more
openaire   +2 more sources

Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy

NMR in Biomedicine, Volume 38, Issue 10, October 2025.
Deuterium magnetic resonance spectroscopy (DMRS) provides a straightforward, noninvasive method for monitoring real‐time metabolic flux. We determined the T1, T2, and chemical shifts for 26 deuterium‐labeled compounds in phosphate‐buffered saline. DMRS showed the consumption of pyruvate, glucose, fumarate, acetone, and nicotinamide, and let us test ...
Fatima Anum, Charbel Assaf, Farhad Haj Mohamad, Maria Anikeeva, Arne Brahms, Jyotirmoy Dey, Simon Kaltenberger, Eric Beitz, Lina Welz, Victoria Annis, Manuel van Gemmeren, Simon Duckett, Jan‐Bernd Hövener, Andrey N. Pravdivtsev   +13 more
wiley   +1 more source

Specific inhibition of the differentiation of Trypanosoma cruzi [PDF]

, 2004
The morphological transformation of Trypanosoma cruzi amastigotes was studied in both mammalian cells and an extracellular differentiation system. Inhibitors of ADP-ribosyl transferase were found to block differentiation in both cases, without affecting ...
Williams, GT
core   +1 more source

Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line [PDF]

, 2003
ObjectiveTo explore inhibition effects of veliparib as PARP inhibitor combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.MethodsBEL-7404 was taken as the object of study and conventional culture was performed.
Yu, Bodley, Sunter, Rouleau, Ellisen, Chalmers, Porcelli, Isakoff, Corcuera, He, Hong, Pachkowski, Farmer, Bryant, Madison, Zhang, Balmañal, Zimmermann   +17 more
core   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Perinatal asphyxia: CNS development and deficits with delayed onset [PDF]

, 2014
Perinatal asphyxia constitutes a prototype of obstetric complications occurring when pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of the period lacking oxygenation, leading to death if not re-established ...
Bustamante, D, Esmar, D, ESPINA MARCHANT, P, GEBICKE HAERTER, Pj, GUTIERREZ HERNANDEZ, M, HERRERA MARSCHITZ, M, Morales, P, Munoz, V, NEIRA PENA, T, Perez, R, Rivera, B, ROJAS MANCILLA, E, Simola, Nicola   +12 more
core   +1 more source

Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study

Cell Reports Medicine
Summary: Preclinical studies suggest synergistic effects between androgen receptor inhibitors and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors.
Tingwei Zhang, Beihe Wang, Yu Wei, Hualei Gan, Bangwei Fang, Xiaomeng Li, Junlong Wu, Xiaojie Bian, Jianfei Wang, Stephen J. Freedland, Shenglin Huang, Dingwei Ye, Yao Zhu   +12 more
doaj   +1 more source