Results 51 to 60 of about 18,599 (272)

Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts

Journal of Obstetrics and Gynaecology, 2023
This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism.
Qin Xue, Wang Enyang, Gong Tingting, Ma Xiaolin, Ma Qipeng, Gao Song   +5 more
doaj   +1 more source

Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin

IJU Case Reports, 2023
Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose ...
Yoshiyuki Miyazawa, Takanori Shimizu, Yoshitaka Sekine, Seiji Arai, Akira Ohtsu, Yuji Fujizuka, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +9 more
doaj   +1 more source

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells [PDF]

, 2008
APLF is a novel protein of unknown function that accumulates at sites of chromosomal DNA strand breakage via forkhead-associated (FHA) domain-mediated interactions with XRCC1 and XRCC4.
Caldecott, Keith W, Cortes-Ledesma, Felipe, Guo, Liandi, Iles, Natasha J, Rulten, Stuart L   +4 more
core   +3 more sources

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]

PLoS Biology, 2016
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan   +8 more
doaj   +1 more source

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report

Journal of Medical Case Reports, 2018
Background Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment ...
Frank S. Fan, Chung-Fan Yang
doaj   +1 more source

The Current State of the Art in PARP Inhibitor-Based Delivery Nanosystems

Pharmaceutics, 2022
Poly (adenosine diphosphate [ADP]–ribose) polymerases inhibitors (PARPi), the first clinically approved drug that exhibits synthetic lethality, are moving to the forefront of cancer treatments.
Lisha Cai, Xiaoling Xu, Wei Chen
doaj   +1 more source