Results 71 to 80 of about 18,215 (242)

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core  

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. [PDF]

, 2005
Summary The family of the poly(adenosine diphosphate-ribose) polymerase (PARP) proteins is directly involved in genomic stability, DNA repair, and apoptosis by DNA damage.
Argenziano G, Bianco AR, Carlomagno C, De Rosa G., Fabbrocini G, Lo Muzio L, Mascolo M, Molea G, Pepe S, Salvatore G, Scalvenzi M, Somma P, Staibano S   +12 more
core   +1 more source

Partial response to niraparib in combination with tislelizumab in a patient with metastatic undifferentiated tonsillar carcinoma: a case report and literature review

Frontiers in Oncology, 2023
Undifferentiated tonsillar carcinoma is an extremely rare head and neck cancer. The treatment options are challenging due to insensitivity to chemotherapy and easy development of drug resistance.
Jing Zhang, Jing Zhang, Zi Dai, Zi Dai, Pei Liao, Pei Liao, Jieshan Guan   +6 more
doaj   +1 more source

Purification and properties of glycohydrolase from calf thymus splitting ribose-ribose linkages of poly(adenosine diphosphate ribose).

Journal of Biological Chemistry, 1974
A new enzyme splitting the ribose-ribose bonds of poly-(adenosine diphosphate ribose) was purified 200-fold from calf thymus. The molecular weight of the enzyme was estimated to be 48,000 by gel filtration and 53,000 by sucrose density gradient ...
M. Miwa, M. Tanaka, T. Matsushima, T. Sugimura   +3 more
semanticscholar   +1 more source

Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells [PDF]

, 2013
published_or_final_versio
Chen, YH, Huang, BM, Lai, MS, Mu, YF, Pan, BS, So, EC, Wang, JY, Wong, STS   +7 more
core   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, EarlyView.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

The plant Nudix hydrolase family. [PDF]

, 2008
Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core  

Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients [PDF]

, 2017
International audienceThe approval, in 2015, of the first poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi; olaparib, Lynparza) for platinum-sensitive relapsed high-grade ovarian cancer with either germline or somatic BRCA1/2 deleterious ...
Banerjee, Susana, Bryce, Jane, Büttner, Reinhard, Capoluongo, Ettore, de Castro, David Gonzalez, Ellison, Gillian, Endris, Volker, Friedman, Eitan, Kamel-Reid, Suzanne, Ligtenberg, Marjolijn J L, Ligtenberg, Marjolijn J.L., López-Guerrero, José Antonio, Markiefka, Birgid, Penault-Llorca, Frédérique, Percival, Natalie, Ray-Coquard, Isabelle, Röthlisberger, Benno, Schirmacher, Peter, Singer, Christian, Soong, Richie, Van Asperen, Christi J, van Asperen, Christi J.   +21 more
core   +4 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review

Frontiers in Oncology, 2022
Ependymoma is the third most common pediatric primary brain tumor, with its most aggressive subtype being posterior fossa group A (PFA). Extraneural metastasis of pediatric PFA ependymoma is rare.
Mading Zhou, Leiming Wang, Peng Sun, Yutong Liu, Ge Chen, Gao Zeng   +5 more
doaj   +1 more source