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The emerging role of poly(ADP-ribose) polymerase-1 in longevity
The International Journal of Biochemistry & Cell Biology, 2005In the present paper, the involvement of the family of poly(ADP-ribose) polymerases (PARPs), and especially of PARP-1, in mammalian longevity is reviewed. PARPs catalyse poly(ADP-ribosyl)ation, a covalent post-translational protein modification in eukaryotic cells.
Alexander, Bürkle +3 more
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Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1
Expert Review of Proteomics, 2011PARP-1 is an abundant nuclear protein that plays an essential role in the regulation of many genome integrity and chromatin-based processes, such as DNA repair, replication or transcriptional regulation. PARP-1 modulates the function of chromatin and nuclear proteins through several poly(ADP-ribose) (pADPr)-dependent pathways.
Emilie, Pic +2 more
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Biochemical Journal, 2015
In this issue of Biochemical Journal, Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases).
Péter, Bai, Balázs, Csóka
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In this issue of Biochemical Journal, Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases).
Péter, Bai, Balázs, Csóka
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Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications
Vascular Pharmacology, 2010Poly(ADP-ribose) polymerases (PARPs) are a family of cell signaling enzymes present in eukaryotes, which are involved in the poly(ADP-ribosylation) of DNA binding proteins. While an 18 member superfamily of PARPs has been identified, however PARP-1 the most abundant isoform accounts for more than 90% of its functions.
Rupinder K, Sodhi +2 more
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Poly(ADP‐ribose) Polymerase–1 Activation During DNA Damage and Repair
2006Changes in chromatin structure emanating from DNA breaks are among the most initiating events in the damage response of the cell. In higher eukaryotes, poly(ADP-ribose) polymerase-1 (PARP-1) translates the occurrence of DNA breaks detected by its zinc-finger domain into a signal, poly ADP-ribose, synthesized and amplified by its DNA-damage dependent ...
Dantzer, Françoise +5 more
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Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease
Neurochemistry International, 2007Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has ...
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Poly(ADP-ribose) polymerase inhibition: past, present and future
Nature Reviews Drug Discovery, 2020Csaba Szabo, Nicola J Curtin
exaly
Poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
Doklady Biochemistry and Biophysics, 2010S N, Khodyreva +4 more
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap, Johann Sebastian de Bono
exaly