Results 241 to 250 of about 98,022 (279)

CCCTC‐binding factor meets poly(ADP‐ribose) polymerase‐1

Journal of Cellular Physiology, 2009
AbstractCCCTC‐binding factor (CTCF) is a ubiquitous Zn‐finger‐containing protein with numerous recognized functions, including, but not limited to, gene activation and repression, enhancer‐blocking, X‐chromosome inactivation, and gene imprinting. It is believed that the protein performs such a variety of functions by interacting with an array of very ...
CAIAFA, Paola, Jordanka Zlatanova
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Niacin, poly(ADP-ribose) polymerase-1 and genomic stability

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001
Nicotinic acid (NA) and nicotinamide (NAM), commonly called niacin, are the dietary precursors for NAD(+) (nicotinamide adenine dinucleotide), which is required for DNA synthesis, as well as for the activity of the enzyme poly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) for which NAD(+) is the sole substrate. The enzyme PARP-1 is highly activated by
Hageman, G.J., Stierum, R.H.
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Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

Experimental Gerontology, 2002
Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally ...
Alexander, Bürkle, Sascha, Beneke, Christine, Brabeck, Alan, Leake, Ralph, Meyer, Marie-Laure, Muiras, Ragen, Pfeiffer   +6 more
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

Journal of Medicinal Chemistry, 2002
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines. In vitro inhibition of PARP-1 was confirmed by direct measurement of NAD+ depletion and ADP-ribose polymer ...
Skalitzky, D., Marakovits, J., Maegley, K., Ekker, A., Yu, X., Hostomsky, Z., Webber, S., Eastman, B., Almassy, R., Li, Curtin, N. J., Newell, D. R., Calvert, A. H., Griffin, R. J., Golding, B. T.   +28 more
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Mediation of cell death by poly(ADP-ribose) polymerase-1

Pharmacological Research, 2005
Poly(ADP-ribosyl)ation plays an important role in modulating the cellular response to stress. The extent of poly(ADP-ribosyl)ation, chiefly via the activation of the poly(ADP-ribose) polymerase-1 (PARP-1), correlates with the severity of genotoxic stress and this determines the cellular response. Under mild and moderate stress, it plays important roles
David W, Koh, Ted M, Dawson, Valina L, Dawson   +2 more
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Poly ADP-ribose polymerase-1: Beyond transcription and towards differentiation

Seminars in Cell & Developmental Biology, 2017
Gene regulation mediates the processes of cellular development and differentiation leading to the origin of different cell types each having their own signature gene expression profile. However, the compact chromatin structure and the timely recruitment of molecules involved in various signaling pathways are of prime importance for temporal and spatial
Tina Jubin, Ashlesha Kadam, Amina Rafath Gani, Mala Singh, Mitesh Dwivedi, Rasheedunnisa Begum   +5 more
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Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update

Apoptosis, 2002
Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in many processes, including DNA repair and cell death. The best known poly(ADP-ribosylating) enzyme, PARP-1, is a DNA nick sensor and uses betaNAD(+) to form polymers of ADP-ribose which are further bound to nuclear protein acceptors.
C, Soldani, A Ivana, Scovassi
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Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2011
Poly(ADP-ribose) polymerases (PARPs) represent a family of enzymes which synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate. PARP-1, the prototypical representative of the family, accounts for the majority of the poly(ADP-ribose) polymer synthesis.
Federica Laudisi, SAMBUCCI M, Claudio Pioli   +2 more
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The role of poly(ADP-ribose) polymerase-1 in CNS disease

Neuroscience, 2007
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that contributes to both neuronal death and survival under stress conditions. PARP-1 is the most abundant of several PARP family members, accounting for more than 85% of nuclear PARP activity, and is present in all nucleated cells of multicellular animals.
T M, Kauppinen, R A, Swanson
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Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors in Cancer Chemotherapy

Recent Patents on Anti-Cancer Drug Discovery, 2006
Poly(ADP-ribose) polymerases (PARPs) are defined as a family of cell signaling enzymes present in eukaryotes, which are involved in poly(ADP-ribosylation) of DNA-binding proteins. The best studied of these enzymes (PARP-1) is involved in the cellular response to DNA damage so that in the event of irreparable DNA damage overactivation of PARP-1 leads to
Victoria, Cepeda, Miguel A, Fuertes, Josefina, Castilla, Carlos, Alonso, Celia, Quevedo, Manual, Soto, José M, Pérez   +6 more
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