Results 231 to 240 of about 98,022 (279)

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

Poly (ADP-ribose) polymerase 1 expression in fibroblasts of Down syndrome subjects

Open Medicine, 2013
Salemi Michele, Barone Concetta, Romano Corrado, Romano Carmelo, Scavuzzo Cataldo, Salluzzo Maria, Tirolo Cataldo, Cantarella Rita, Ragalmuto Alda, Paola Sandro, Bosco Paolo   +10 more
doaj   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

Piceid Octanoate Protects Retinal Cells against Oxidative Damage by Regulating the Sirtuin 1/Poly-ADP-Ribose Polymerase 1 Axis In Vitro and in rd10 Mice. [PDF]

Antioxidants (Basel)
Moshtaghion SM, Caballano-Infantes E, Plaza Reyes Á, Valdés-Sánchez L, Fernández PG, de la Cerda B, Riga MS, Álvarez-Dolado M, Peñalver P, Morales JC, Díaz-Corrales FJ.   +10 more
europepmc   +1 more source

Beyond Glucose: A Brain Energy Bottleneck Hypothesis for Multi‐Energy Substrates in Hypoglycaemia Rescue

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3474-3479, May 2026.
D. Russell‐Jones, M. Laffan, J. Mader
wiley   +1 more source

Poly(ADP-ribose) polymerase-1 affects vasopressin-mediated AQP2 expression in collecting duct cells of the kidney.

Am J Physiol Renal Physiol
Jang HJ, Park E, Jung HJ, Kwon TH.
europepmc   +1 more source

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Poly (ADP-ribose) polymerase 1

2022
Poly (ADP-ribose) polymerase 1 is a key player in DNA repair and transcription regulation. The role of PARP1 in DNA damage recognition and protein signaling in response make it integral to genome stability. Beyond this, it regulates gene expression through chromatin remodeling and transcription factor binding.
Fletcher E Bain, Maria Spies, Marc Wold, Adrian Elcock, Anna Malkova, Miles Pufall, Lori Wallrath   +6 more
openaire   +1 more source

Novel poly(ADP-ribose) polymerase-1 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2007
Synthesis and activity of a series of 3-aroyl-derived analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are disclosed.
Derek, Dunn, Jean, Husten, Mark A, Ator, Sankar, Chatterjee   +3 more
openaire   +3 more sources

Natural Inhibitors of Poly(ADP-ribose) Polymerase-1

Molecular Neurobiology, 2012
Poly(ADP-ribose) polymerases (PARPs) are enzymes that catalyze the transfer of ADP-ribose units from β-nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins. PARP-1 is responsible for more than 90 % of protein poly-ADP-ribosylation in the brain and may play a role as a molecular switch for cell survival and death. The functional roles of PARP-
Marek, Banasik, Todd, Stedeford, Robert P, Strosznajder   +2 more
openaire   +2 more sources