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Natural Inhibitors of Poly(ADP-ribose) Polymerase-1
Molecular Neurobiology, 2012Poly(ADP-ribose) polymerases (PARPs) are enzymes that catalyze the transfer of ADP-ribose units from β-nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins. PARP-1 is responsible for more than 90 % of protein poly-ADP-ribosylation in the brain and may play a role as a molecular switch for cell survival and death. The functional roles of PARP-
Marek, Banasik +2 more
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Poly(ADP-ribose) polymerase and aging
2001Publisher Summary Poly(ADP-ribose) polymerase (PARP) is a major nuclear protein associated with chromatin that contains zinc fingers and binds to either double- or single-strand DNA breaks. Upon binding to DNA, PARP is activated and forms covalent homopolymers of poly(ADP-ribose) (PAR) attached to a number of nuclear proteins, including itself and ...
Dean S. Rosenthal +3 more
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Enzymatic properties of poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin
1992The catabolism of NAD+ in cells is carried out by poly(ADP-ribose) polymerase (PARP) which converts NAD+ into poly(ADP-ribose) in response to DNA damage. All the evidence that has accumulated up to now indicates that the degradation of poly(ADP-ribose) in vivo is carried out by poly(ADP-ribose) glycohydrolase (the glycohydrolase) and not by a ...
Hélène Thomassin +6 more
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Erasable Blot of Poly(ADP-ribose) Polymerase
Analytical Biochemistry, 1994S, Desnoyers +3 more
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap +2 more
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