Results 211 to 220 of about 9,107 (249)

Regulatory mechanisms of poly(ADP-ribose) polymerase

Molecular and Cellular Biochemistry, 1999
Here, we describe the latest developments on the mechanistic characterization of poly(ADP-ribose) polymerase (PARP) [EC 2.4.2.30], a DNA-dependent enzyme that catalyzes the synthesis of protein-bound ADP-ribose polymers in eucaryotic chromatin. A detailed kinetic analysis of the automodification reaction of PARP in the presence of nicked dsDNA ...
R, Alvarez-Gonzalez, T A, Watkins, P K, Gill, J L, Reed, H, Mendoza-Alvarez   +4 more
openaire   +2 more sources

Interaction of poly(ADP-ribose)polymerase with DNA polymerase ?

Molecular and Cellular Biochemistry, 1994
Homogeneously purified poly(ADP-ribose) polymerase (PARP) specifically stimulated the activity of immunoaffinity-purified calf or human DNA polymerase alpha by about 6 to 60-fold. Apparently, poly(ADP-ribosyl)ation of DNA polymerase alpha was not necessary for the stimulation.
S, Yoshida, C M, Simbulan
openaire   +2 more sources

Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry

The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper, L, van Gool, M, Müller, A, Bürkle   +3 more
openaire   +2 more sources

Poly(ADP‐ribose) polymerase: Molecular biological aspects

BioEssays, 1991
AbstractA number of roles have been ascribed to poly(ADP‐ribose) polymerase* including involvement in DNA repair, cell proliferation, differentiation and transformation. Cloning of the gene has allowed the development of molecular biological approaches to elucidate the structure and the function(s) of this highly conserved enzyme.
Murcia, G, Menissier-de Murcia, J, Schreiber, V   +2 more
openaire   +2 more sources

Poly(ADP-ribose) polymerase: Structure-function relationship

Biochimie, 1995
Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes.
M. Masson, V. Rolli, F. Dantzer, C. Trucco, V. Schreiber, S. Fribourg, M. Molinete, A. Ruf, E. Alves Miranda, C. Niedergang, D. Hunting, B. Gowans, G.E. Schulz, J.Ménissier de Murcia, G. de Murcia   +14 more
openaire   +2 more sources

Poly(ADP-ribose) polymerase and aging

Experimental Gerontology, 1998
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Erasable Blot of Poly(ADP-ribose) Polymerase

Analytical Biochemistry, 1994
S, Desnoyers, G M, Shah, G, Brochu, G G, Poirier   +3 more
openaire   +2 more sources

Arabidopsis sirtuins and poly( ADP ‐ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms

Plant, Cell and Environment, 2021
Matthew A Hannah, Alex Webb, Jun Hyeok Kim   +2 more
exaly  

Poly(ADP-Ribose) Polymerase

2023
openaire   +1 more source

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Ca-A Cancer Journal for Clinicians, 2011
Johann S de Bono, Timothy A Yap, Shahneen Sandhu   +2 more
exaly