Results 91 to 100 of about 6,764 (212)

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family.
Yueshuang Ke, Chenxin Wang, Jiaqi Zhang, Xiyue Zhong, Ruoxi Wang, Xianlu Zeng, Xueqing Ba   +6 more
doaj   +1 more source

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes [PDF]

, 2009
Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm contain a number of molecules and pathways for the repair of base excision, base mismatches and DNA strand breaks.
Ashok Agarwal, Reda Z Mahfouz, Rakesh K Sharma, Oli Sarkar, Devna Mangrola, Premendu P Mathur, T Ogawa, F Suzuki-Toyota, K Toshimori, RJ Aitken, I Amiri, F Kappes, DN Tripathi, D Sakkas, P Patrizio, E Seli, J Tesarik, MM El-Domyati, RM Laberge, RM Laberge, F Leduc, RK Sharma, A Agarwal, A Agarwal, A Agarwal, A Agarwal, M Bungum, J Erenpreiss, M Muratori, SE Lewis, K Tremellen, TE Schmid, KC Chitra, P Mathur, AK Olsen, JC Rockett, B Saradha, N Desai, A Agarwal, D Gero, JP Gagne, AM Reed, S Di Meglio, AP Sinha Hikim, ML Meyer-Ficca, L Atorino, D Sakkas, O Stahl, RZ Mahfouz, SE Lewis, A Zini, S Horak, Z Li, MH Nasr-Esfahani, C Niederberger, C Paul, V Schreiber, C Flohr, JC Ame, PO Hassa, DA Wacker, V Schreiber, A Augustin, M Baumgartner, BW Cherney, BC Woodhouse, D D'Amours, PO Hassa, MF Langelier, Z Tao, V Schreiber, E Pion, M Altmeyer, T Zaremba, N Ogata, J Diefenbach, H Mendoza-Alvarez, P Adamietz, GG Poirier, L Atorino, H Mendoza-Alvarez, K Yoshihara, AI Scovassi, M Kameoka, K Huang, PI Bauer, U Kolthur-Seetharam, G Ermak, T Schwerdtle, R Midorikawa, E Mocchegiani, E Kun, L Geraets, TM Kauppinen, Y Ariumi, M Audebert, J Chen, P Kotoglou, JB Leppard, F Dantzer, JL Parsons, D Sagan, D Quenet, O Mortusewicz, O Ullrich, J Mathieu, JT Heeres, FJ Oliver, M Zerfaoui, SH Kaufmann, D D'Amours, SW Yu, F Tramontano, A Tulin, NA Berger, SA Andrabi, M Kanai, P Chang, M Kanai, E Earle, A Saxena, MR Faraone-Mennella, WL Kraus, WL Kraus, D Quenet, JY Huang, GG Poirier, M Rouleau, R Krishnakumar, SL Oei, T Yazawa, K Ye, K Mizuno, O Varisli, M Tanori, V Spina-Purrello, W Yu, NA Thornberry, O Ullrich, E Klenova, T Guastafierro, E Winstall, L Davidovic, DW Koh, C Blenn, AE Fisher, JS Baum, CG Print, VA Codelia, Y Ohashi, V Spina-Purrello, M Tewari, P Pacher, PJ Duriez, F Hadziselimovic, WW Lin, SK Kim, J Tesarik, BB Maymon, F Dantzer, AP Hikim, M Miura, R Aguilar-Quesada, V Pentikainen, A Chiarugi, S Di Meglio, P Quesada, D Wouters-Tyrou, WS Ward, L Marcon, ML Meyer-Ficca, A Kaipia, SL Taylor, R Jha, M Benchaib, J Kopeika, M Meseguer, C O'Flaherty, A Edelstein, JR Spermon, RT Mitchell, T Wang, Y Wang, GJ Olsen, IV Kovtun, IV Kovtun, IV Kovtun, E Trushina, D Rybaczek, F Leduc, P Quesada, F Tramontano, S Jaroudi, C Marchetti, U Paasch, S Grunewald, C Almeida, SL Weng, U Paasch, L Faleiro, B Buelow, B Xu, G Blanc-Layrac, MM El-Domyati, RZ Mahfouz, JC Kefer, K Makker, M Reddy, R Mahfouz, S Vaithinathan, O Sarkar, B Saradha, O Sarkar, K Erdelyi, H Chen, PG Chandak, SF El-Khamisy, Y Liang, M Ljungman, SH Huang, P Lin, Q Ma, S Beneke, O Cohausz, HJ Chiu, F Dantzer, M Gomez, S Smith, CM Simbulan-Rosenthal, F d'Adda di Fagagna, RJ Aitken, RJ Aitken, RZ Mahfouz, S Adhikari, CA de la Lastra, P Zhang   +235 more
core   +1 more source

Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing [PDF]

Nucleic Acids Research, 2009
The biological functions of poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins (hnRNPs) are not well understood. However, it is known that hnRNPs are involved in the regulation of alternative splicing for many genes, including the Ddc gene in Drosophila.
Ji, Yingbiao, Tulin, Alexei V.
openaire   +2 more sources

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, Volume 24, Issue 9, September 2025.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Poly (ADP‐Ribose) Glycohydrolase‐Dependent dePARylation of PCNA Is Essential for DNA Replication

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
The schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Zhenzhen Yan, Qianxi Feng, Xiuhuan Jiang, Xiaoru Han, Zichang Qiao, Yaguang Wang, Xiaoyun Yang, Xiuhua Liu, Xinying Cheng, Shuai Guo, Hongyan Li, Chen Wu   +11 more
wiley   +1 more source

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, Volume 37, Issue 22, June 5, 2025.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core