Results 111 to 120 of about 6,764 (212)

Inhibition of GSDMD Activates Poly(ADP-ribosyl)ation and Promotes Myocardial Ischemia-Reperfusion Injury. [PDF]

Oxid Med Cell Longev, 2022
Zhang ZH, Zhang ZG, Chen MW, Yang Y, Li RJ, Xu JJ, Yang C, Li YY, Chen HW, Liu SX, Li YL, Luo P, Liu YJ, Chen WB, Shan ZG, Huang ZR.   +15 more
europepmc   +1 more source

Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling. [PDF]

Int J Mol Sci, 2022
Mashimo M, Kita M, Uno A, Nii M, Ishihara M, Honda T, Gotoh-Kinoshita Y, Nomura A, Nakamura H, Murayama T, Kizu R, Fujii T.   +11 more
europepmc   +1 more source

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage. [PDF]

Cell Commun Signal, 2022
Liu HY, Liu YY, Zhang YL, Ning Y, Zhang FL, Li DQ.   +5 more
europepmc   +1 more source

Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination. [PDF]

Mol Plant, 2021
Yao D, Arguez MA, He P, Bent AF, Song J.
europepmc   +1 more source

NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

Cell Reports
Summary: We identified poly(ADP-ribose) polymerase 7 (PARP7), a mono(ADP-ribosyl) transferase, as a regulator of C/EBPβ-dependent proadipogenic gene expression.
MiKayla S. Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Chenqian Liu, Morgan Dasovich, Josue Zuniga, Tulip Nandu, Dan Huang, Thomas P. Mathews, Ashley Solmonson, Cristel V. Camacho, W. Lee Kraus   +13 more
doaj   +1 more source

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs. [PDF]

Oncotarget, 2022
Valdez BC, Nieto Y, Yuan B, Murray D, Andersson BS.   +4 more
europepmc   +1 more source

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. [PDF]

Acta Pharm Sin B, 2021
Li Z, Guo Z, Lan R, Cai S, Lin Z, Li J, Wang J, Li Z, Liu P.   +8 more
europepmc   +1 more source

PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in Embryonic Stem Cells

Cells
Poly(ADP-ribosyl)ation is a crucial posttranslational modification that governs gene expression, chromatin remodeling, and cellular homeostasis. This dynamic process is mediated by the opposing activities of poly(ADP-ribose) polymerases (PARPs), which ...
Yaroslava Karpova, Sara Piatz, Guillaume Bordet, Alexei V. Tulin   +3 more
doaj   +1 more source

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context. [PDF]

Sci Rep, 2021
Kutuzov MM, Belousova EA, Kurgina TA, Ukraintsev AA, Vasil'eva IA, Khodyreva SN, Lavrik OI.   +6 more
europepmc   +1 more source

PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress

Nature Communications
PARP2 is a DNA-dependent ADP-ribosyl transferase (ARTs) enzyme with Poly(ADP-ribosyl)ation activity that is triggered by DNA breaks. It plays a role in the Base Excision Repair pathway, where it has overlapping functions with PARP1.
Daniela Muoio, Natalie Laspata, Rachel L. Dannenberg, Caroline Curry, Simone Darkoa-Larbi, Mark Hedglin, Shikhar Uttam, Elise Fouquerel   +7 more
doaj   +1 more source