Results 11 to 20 of about 6,764 (212)
Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection [PDF]
Cell ReportsSummary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair.
Julie Rageul +5 more
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PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease
MedCommThe poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei +9 more
doaj +2 more sources
Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells. [PDF]
Biochim Biophys Acta Gene Regul Mech, 2018 CTCF is an evolutionarily conserved and ubiquitously expressed architectural protein regulating a plethora of cellular functions via different molecular mechanisms. CTCF can undergo a number of post-translational modifications which change its properties
Pavlaki I +7 more
europepmc +2 more sources
Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export. [PDF]
Cell Death Differ, 2016 AMPK is a central energy sensor linking extracellular milieu fluctuations with the autophagic machinery. In the current study we uncover that Poly(ADP-ribosyl)ation (PARylation), a post-translational modification (PTM) of proteins, accounts for the spatial and temporal regulation of autophagy by modulating AMPK subcellular localisation and activation ...
Rodríguez-Vargas JM +10 more
europepmc +8 more sources
Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease [PDF]
Experimental and Molecular MedicineSmooth muscle cells are remarkably plastic. Their reversible differentiation is required for growth and wound healing but also contributes to pathologies such as atherosclerosis and restenosis.
Wenjing Xu +9 more
doaj +2 more sources
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. [PDF]
Cell Cycle, 2014 Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis.
Li M, Bian C, Yu X.
europepmc +4 more sources
Scientific Reports, 2022 In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a promising surrogate for clinical activity onto difficult-to-treat cancers. Here we explored the
Leonel Nguekeu-Zebaze +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation ...
Nikita V. Savelyev +10 more
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Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
core +12 more sources
PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses. [PDF]
PLoS Genetics, 2015 Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly(ADP-ribose) units onto target proteins. Poly(ADP-ribosyl)ation plays a crucial role in a variety of cellular processes including, most prominently, auto-activation of PARP at ...
Junqi Song +3 more
doaj +1 more source