Results 81 to 90 of about 6,764 (212)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, Volume 599, Issue 22, Page 3355-3368, November 2025.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Why is DNA methylation of Igf2 CpG island shore affected during ageing? [PDF]

, 2012
Comment on: Pirazzini C, Giuliani C, Bacalini MG, Boattini A, Capri M, Fontanesi E, Marasco E, Mantovani V, Pierini M, Pini E, Luiselli D, Franceschi C. Garagnani P.
CAIAFA, Paola, ZAMPIERI, Michele
core   +2 more sources

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging.
Federica Novazzi, Pietro Giorgio Spezia, Francesca Drago Ferrante, Angelo Paolo Genoni, Paolo Antonio Grossi, Nicasio Mancini, Marco Malavolta, Marta Balietti, Francesco Piacenza, Serena Marcozzi, Carlo Fortunato, Gretta Veronica Badillo Pazmay, Laura Cianfruglia, Alexander Bürkle, María Moreno‐Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Michele Zampieri, Paola Caiafa, Fabio Ciccarone, Anna Reale, Birgit Weinberger, Ewa Sikora, Florence Debacq‐Chainiaux, Wolfgang Stuetz, Mikko Hurme, P. Eline Slagboom, Jürgen Bernhardt, Fabiola Olivieri, Fabio Filippini, Fabrizio Maggi, Robertina Giacconi   +35 more
wiley   +1 more source

LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

Genome Biology, 2022
Background Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the ssDNA-RPA intermediate is regulated
Kaiwen Bao, Qi Zhang, Shuai Liu, Nan Song, Qiushi Guo, Ling Liu, Shanshan Tian, Jihui Hao, Yi Zhu, Kai Zhang, Ding Ai, Jie Yang, Zhi Yao, Roland Foisner, Lei Shi   +14 more
doaj   +1 more source

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose) dependent pathway in the early response to DNA-damaging agents [PDF]

, 2007
Poly(ADP-ribosyl)ation is a post-translational modification that is instantly stimulated by DNA strand breaks creating a unique signal for the modulation of protein functions in DNA repair and cell cycle checkpoint pathways.
Adamson, Andrabi, Appella, Bakkenist, Beamish, Beardsley, Bouchard, Bryant, Bryant, Calabrese, Canman, Chalmers, Chang, Chang, Du, El-Khamisy, Fang, Farmer, Fernandes, Gagne, Goodarzi, Haince, Hochegger, Huber, Jacobson, Karras, Khanna, Kim, Kitagawa, Lavin, Lee, Leppard, Lindahl, Malanga, Malanga, Malanga, McCabe, Menisser-de Murcia, Menissier de Murcia, Noel, O'Driscoll, Pandita, Pleschke, Plummer, Poirier, Sawada, Schultz, Shah, Shall, Shiloh, Stojic, Takahashi, Tartier, Valenzuela, Wang, Wang, Wieler, Young, Yu, Zelphati   +59 more
core   +1 more source

Biological Roles of Mono- and Poly (ADP-Ribosyl) ation

Journal of Nutritional Science and Vitaminology, 1992
Biological roles of mono- and poly (ADP-ribosyl) ation reactions are reviewed, along with analysis of functional sequences of poly(ADP-ribose) synthetase and inhibitors of the synthetase compared with mono (ADP-ribosyl) transferase.
K, Ueda, M, Banasik, I, Saito, T, Kido, B R, Das, N A, Abed, H, Komura   +6 more
openaire   +3 more sources

Effect of zinc on cellular poly(ADP-ribosyl)ation capacity [PDF]

Experimental Gerontology, 2008
Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process.
Kunzmann, Andrea, Dedoussis, George, Jajte, Jolanta, Malavolta, Marco, Mocchegiani, Eugenio, Bürkle, Alexander   +5 more
openaire   +3 more sources

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites [PDF]

, 2017
Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not been ...
Altmeyer, Matthias, Fey, Monika, Hassa, Paul O., Hottiger, Michael O., Messner, Simon   +4 more
core  

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1 [PDF]

, 2012
The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER). However, how DDB2 promotes NER in chromatin is poorly understood.
Aboussekhra, Ahel, Alex Pines, André Deelder, Anton de Groot, Bryant, Cleaver, Cleaver, Clement, Cohen-Armon, Datta, Deng, Dimitris Typas, Dinant, Fischer, Fitch, Fousteri, Friedberg, Gagné, Gillet, Gottschalk, Groisman, Harry Vrieling, Hassa, Houtsmuller, Hwang, Jurgen A. Marteijn, Kaoru Sugasawa, Kapetanaki, Kim, Krishnakumar, Leon Mullenders, Luijsterburg, Luijsterburg, Luijsterburg, Martijn S. Luijsterburg, Martin, Martinez, Medine Cansoy, Messner, Messner, Min, Mischa G. Vrouwe, Moné, Moser, Moser, Mu, Nicolas Thoma, Nishi, Overmeer, Palomera-Sanchez, Paul Hensbergen, Pines, Rajamohan, Rapić Otrin, Rapić-Otrin, Schultz, Scrima, Shiyanov, Slade, Sugasawa, Sugasawa, Sugasawa, Syota Matsumoto, Tang, Timinszky, Vodenicharov, Volker, Wang, Wim Vermeulen, Wittschieben, Zotter   +71 more
core   +3 more sources