Results 161 to 170 of about 581,069 (219)

Antibodies to Poly(I) · poly(C)

European Journal of Biochemistry, 1976
Sera of rabbits immunized with poly(I) · poly(C) adsorbed to methylated serum albumin react with poly(I) · poly(C), poly(I) and poly(C). Three families of antibodies have been isolated by affinity chromatography.The antibodies to poly(I) · poly(C) precipitate poly(I) · poly(C) but neither poly(I) nor poly(C).
Michèle GUIGUES, Marc LENG
openaire   +1 more source

Hemostatic toxicity of poly I-C

Toxicology and Applied Pharmacology, 1972
Abstract Intravenous therapy in beagles with Poly I-C resulted in a dose-related toxicity. In animals receiving 3.0 mg/kg, the clinical and pathological evidence indicated that disseminated intravascular coagulation (DIC) led directly to their death. In animals receiving 0.3 mg/kg evidence for DIC was present both by clinical and pathological studies;
H R, Gralnick, L L, Shott, R P, Zendzian, E, Homan   +3 more
openaire   +2 more sources

Interaction of poly(I) and poly(I)·poly(C) with chlorodiethylenetriamino platinum(II) chloride

Biopolymers, 1984
AbstractThe fixation of dien‐Pt on poly(I)·poly(C) leads to only minor changes in the uv and CD spectra at ambient temperature, showing that there is little perturbation of the secondary structure in the rb range studied (up to 0.30). However, the melting profiles show two steps.
D, Hermann, G V, Fazakerley, W, Guschlbauer   +2 more
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A Putative Interferon Induced in Hamsters by Poly(I) · Poly(C)

Journal of Interferon Research, 1981
Encephalomyocarditis (EMC) virus causes lethal infection of hamsters against which poly(I) . poly(C) causes dose-dependent protection. In contrast, no antiviral effects occur with poly(I) . poly(C) against influenza virus infection of hamsters. Serum from poly(I) .
E M, Round, N, Stebbing
openaire   +2 more sources

Induction of Interferon by ‘Sepharose’-bound Poly(I).Poly(C)

Nature New Biology, 1973
SYNTHETIC polynucleotides, in particular the double stranded polyribonucleotides, can induce viral resistance and interferon production both in animals and in cells grown in culture1. One approach to the problem of interferon induction is to learn whether the receptor sites for these interferon inducers are intracellular or located in the cell membrane.
J, Taylor-Papadimitriou, J, Kallos
openaire   +2 more sources

Effect of non‐complementary nucleotides on the rate of helix formation: Kinetics of formation of poly (I)·poly (C,I) and poly (I)·poly (C,U) complexes

Biopolymers, 1972
AbstractApparent second‐order rate constants for complex formation between poly (I) and poly (C) and copolymers of C containing non‐complementary I or U residues have been determined spectrophotometrically. The rate constants decrease as the concentration of either I or U in the C strands increases–the effect seems insensitive to the species of residue
N R, Kallenbach, S D, Drost
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Study of the interaction of cis-dichloro-(1,2 diethyl-3-aminopyrrolidine)Pt(II) complex with poly(I), poly(C) and poly(I)·poly(C)

Journal of Inorganic Biochemistry, 2001
The interaction of cis-dichloro-(1,2 diethyl-3-aminopyrrolidine)platinum(II) (Ptpyrr) with the polynucleotides poly(I), poly(C) and poly(I) x poly(C) acids was studied by circular dichroism, molecular fluorescence and (1)H NMR spectroscopies. Multivariate Curve Resolution, a factor analysis method, was applied for the analysis and interpretation of ...
M, Vives, R, Gargallo, R, Tauler, V, Moreno   +3 more
openaire   +2 more sources