Results 181 to 190 of about 581,069 (219)

Proton‐NMR study of the interaction of trans‐dichloro‐diamine‐platinum(II) with poly(I) and poly(I)·poly(C)

Biopolymers, 1984
AbstractThe fixation of trans‐(NH3)2Cl2 Pt(II) to poly(I)·poly(C) at low rb (< 0.05) leads to the formation of two complexed species. The major species (ca. 82% of bound platinum) involves coordination of platinum to a single hypoxanthine base, while the other species involves coordination of two hypoxanthine bases, which are either far apart on the
G V, Fazakerley, D, Hermann, W, Guschlbauer, G E, Hawkes   +3 more
openaire   +2 more sources

[Acute toxicity and cumulative properties of poly(I).poly(C) and poly(G).poly(C) polyribonucleotide complexes].

Farmakologiia i toksikologiia, 1981
Acute experiments on mice and rats were made to determine the intraperitoneal lethal doses of the polyribonucleotide complexes poly (I).poly (C) and poly (G).poly (C) manufactured in this country. Changes in the function of cardiovascular, nervous, thermoregulatory and motor systems seen after injection of both complexes were shown to have some ...
V I, Masycheva, I G, Nadolinnaia
openaire   +1 more source

Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA

Nature, 1970
X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.
Y, Mitsui, R, Langridge, B E, Shortle, C R, Cantor, R C, Grant, M, Kodama, R D, Wells   +6 more
openaire   +2 more sources

Interaction of Antitumor Agent Mitoxantrone with Double Helical Synthetic Polyribonucleotides Poly(G)⋅Poly(C) and Poly(I)⋅Poly(C)

Biophysical Reviews and Letters, 2017
The interaction of antitumor drug mitoxantrone (MTX) with double-stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-Visible absorption, circular dichroism) techniques. The results show a base specificity in this interaction: the association constant with poly(G)[Formula: see text]poly(C) is higher than with poly(I ...
Yuri S. Babayan, Sergey N. Hakobyan, Rusanna S. Ghazaryan, Mariam A. Shahinyan   +3 more
openaire   +1 more source

Evaluation of a Nuclease-Resistant Derivative of Poly(I)·Poly(C) [Poly(ICLC)] as a Radioprotective Agent

Radiation Research, 1979
Intramuscular injection of a stabilized polyriboinosinic acid·polyribocytidylic acid complex, composed of the two acids poly-l-lysine and carboxymethylcellulose [poly(ICLC)], was radioprotective in mice when given in single or multiple doses before total-body irradiation.
W B, Baze, E, Lvovsky, G A, Higbee, H B, Levy, D E, Hilmas   +4 more
openaire   +2 more sources

Induction of human leukocyte interferon by heat-treated poly I: Poly C

Biochemical and Biophysical Research Communications, 1983
Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN). When poly I: poly C solution was heated at 37 - 65 degrees C for 30 minutes, high activity of human IFN (10,000 - 60,000 ...
M, Tamura, S, Sasakawa
openaire   +2 more sources

In vitro stimulation of spleen cell cultures by poly I: Poly C and levamisole

Cellular Immunology, 1974
Abstract Poly I: poly C and levamisole (LMS) were shown to stimulate DNA synthesis by spleen cell suspension cultures. Poly I: poly C was more effective than LMS at concentrations above 1 μg/ml; both agents were weakly stimulatory at concentrations 0.1–1.0 μg/ml.
Woods, W A, Siegel, M J, Chirigos, M A
openaire   +2 more sources

Studies on the Anti-Tumor Action of Poly I: Poly C

1971
During the past year there has been a good deal of interest in various aspects of the antitumor action of poly I:poly C., ranging from basic studies of the mechanism of its action to the beginning of therapeutic trials in humans with malignant disease. This discussion will touch on both of these areas of interest.
H. B. Levy, R. Adamson, P. Carbone, V. DeVita, A. Gazdar, J. Rhim, A. Weinstein, F. Riley   +7 more
openaire   +1 more source

Sepharose-bound poly(I).poly(C): Interaction with cells and interferon production

Biochemical and Biophysical Research Communications, 1975
Abstract Poly(I).poly(C) covalently coupled to a matrix by one point fixation through its 3′ terminal stimulated both antiviral activity and interferon production in primary rabbit kidney (PRK) cells. This effect could not be accounted for by free polynucleotide released from the matrix into the medium.
L, Bachner, E, De Clercq, M N, Thang
openaire   +2 more sources

Relationship of Biological Activities of Poly I · Poly C to Homopolymer Molecular Weights

Nature New Biology, 1971
RECENT studies indicate that the antiviral activity of the double strand polyribonucleotide poly I·poly C is sensitive to the size of the component homopolymers, poly I and poly C1. These studies have relied on various molecular weight approximations, for specific equations relating physical properties of poly I and poly C to molecular weight have not ...
J F, Niblack, M B, McCreary
openaire   +2 more sources