Results 171 to 180 of about 581,069 (219)

Production and Characterization of Poly(I):Poly(C)-Induced Rat Interferons In Vitro

Journal of Interferon Research, 1986
The synthetic polyribonucleotide polyinosinate:polycytidylate [poly(I):poly(C)] was used to induce interferon (IFN) production in a rat leiomyosarcoma cell line. Three separate IFN species were distinguished by antiviral activity on homologous and heterologous cells, interaction with Blue Sepharose CL-6B chromatography matrix, and antibody ...
D L, Wiedbrauk, G R, Burleson
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Relationships between the Effects of Poly I . Poly C and Endotoxin

Nature, 1969
RECENT communications1–3 have called attention to the toxicity of poly I . poly C and noted the resemblance of some of these effects to known endotoxin effects. The fact that “although poly I . poly C and endotoxin share many similarities, they are not identical in action”1 is also documented by the ability of endotoxin and poly I . poly C to stimulate
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Morphological Changes in Chick Cerebellum induced by Poly I · Poly C

Nature, 1970
A COMPLEX of polyinosinic acid and polycytidylic acid (poly I · poly C) induces resistance to viral infections in mice1 and is an effective inducer of interferon in rabbits1,2 and mice3. This antiviral drug has been used in the treatment of herpetic keratoconjunctivitis in rabbits4, against viral tumours in mice5,6, and in clinical trials in patients ...
P A, Young, J J, Taylor, M C, Yu, E, Eyerman   +3 more
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Acute induction of joint inflammation in the rat by Poly I � Poly C

Inflammation, 1979
Intraarticular injection of interferon inducer, double-stranded polyinosinate-polycytidylate (Poly I . C) caused acute synovitis in rats. This acute inflammatory response was accompanied by an increased concentration of prostaglandin E (PGE) in the synovial tissue. Double-stranded polyadenylate-polyuridylate (Poly A .
M, Yaron, M, Baratz, I, Yaron, U, Zor
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Interferon induction by platinum(II)-poly(I)·poly(C) complexes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1983
The effect of the interaction between poly(I).poly(C) and cis-dichloro-diammineplatinum(II) (cis-Pt), its trans analogue and chloro-diethylene-triamminoplatinum(II) (dien-Pt) on interferon induction activity was investigated. The covalent monodentate fixation of the three compounds on N7 of inosine has different effects on the structure and ...
E, De Clercq, D, Hermann, W, Guschlbauer
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Demonstrations of the Production of Specific Antibodies to Poly(I) . poly(C) in Rabbits

The Journal of Biochemistry, 1980
The rabbit antiserum against poly(I).poly(C) purified by hydroxyapatite column chromatography contained three distinct antibodies. They were fractionated into three antibody populations by a series of precipitations (with poly(A).poly(U), poly(I), and poly(I).poly(C)) and their specificities were examined by quantitative complement fixation, double ...
Y, Kitagawa, E, Okuhara
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Poly I-Mercapto Poly C: Antiviral, Anticellular, and Pharmacologic Effects

Journal of Urology, 1985
Thiolation of position 5 of some of the cytosine bases in polycytidylic acid results in the formation of mercaptopolycytidylic acid (MPC). Annealing of MPC to polyinosinic acid (Poly I) results in the formation of double-stranded Poly I-MPC. In this study we investigated the interferon inducing ability, in vivo toxic effects, effect on DNA synthesis ...
K A, Vastola, Y K, Ho, T J, Bardos, B J, Grossmayer, L, Fruck-Diviak, J A, O'Malley   +5 more
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Toxicity of Poly I.Poly C for Rabbit Eyes

Nature, 1970
A SYNTHETIC polyriboinosinic acid.polyribocytidylic acid complex (poly I.poly C) is known to be a potent inducer of interferon1 and to mediate resistance to various viral and nonviral infections in vivo and in vitro. Recently poly I.poly C was reported to be effective in herpetic keratitis in rabbits without producing any evidence of local or systemic ...
H B, Ostler, J O, Oh, C R, Dawson, W L, Burt   +3 more
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Deuterium NMR in the solid-state and in solution of the molecular motion of the bases in poly(I) and poly(I)·poly(C)

Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
To provide information regarding the conformational flexibility of nucleic acids, in particular the rate and amplitude of base motions, we have observed the deuterium NMR from single-stranded and double-stranded polynucleotides. Poly(I) was deuterated at the 8-position of the base, and the deuterium NMR was examined in solution (at 23.0 and 55.4 MHz ...
P, Bendel, J, Murphy-Boesch, T L, James
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[Radioprotective action of a combination of poly I-poly C and mexamine].

Radiobiologiia, 1984
In experiments on (CBA X C57Bl)F1 mice irradiated with doses of 8-12 Gy a study was made of the effect of a mixture of polyI-polyC (2.5 mg/kg, 2 days before irradiation) and mexamine (30 mg/kg, 5 min before irradiation) on the survival rate of animals and the times of their death.
N A, Zhulova, G F, Palyga, A A, Maksimenko, A, Vacek   +3 more
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