Results 111 to 120 of about 20,290 (148)

Phase I Trial with the Interferon Inducer Poly I:C/Poly-L-Lysine (Poly ICL)

Journal of Interferon Research, 1983
Poly I:C/poly-L-lysine (poly ICL) was previously shown to be a potent inducer of interferon (IFN) production in nonhuman primates. In this limited trial in five patients with advanced cancer, poly ICL stimulated primarily leukocyte interferon (IFN-α) with peak titers of 40 to 160 units/ml, usually at 24 hours after poly ICL administration.
S.E. KROWN, G.B. FRIDEN, T. KHANSUR, M.E. DAVIES, H.F. OETTGEN, A.K. FIELD   +5 more
openaire   +1 more source

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

Advanced Drug Delivery Reviews, 2008
Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). TLR3 is expressed both intracellularly and on
Misako, Matsumoto, Tsukasa, Seya
openaire   +2 more sources

Effect of Poly I:C/poly-L-lysine (poly ICL) on the Development of Murine Osteogenic Sarcoma

Journal of Interferon Research, 1983
Poly I:C/poly-L-lysine (poly ICL) was effective in preventing or delaying the development of osteogenic sarcoma (OGS) in mice. C57BL/6J mice were inoculated subcutaneously with 5 X 10(4) OGS cells and treatment was evaluated by palpable tumor development and subsequent day of death.
M E, Davies, A K, Field
openaire   +2 more sources

The reduction of voluntary physical activity after poly I:C injection is independent of the effect of poly I:C-induced interferon-beta in mice

Physiology & Behavior, 2008
One characteristic of sickness behavior in mice is demonstrated by a reduction in voluntary wheel-running activity during infection. Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense.
Takashi, Matsumoto, Hiroshi, Takahashi, Daisuke, Shiva, Noriaki, Kawanishi, Michael J, Kremenik, Yasuko, Kato, Hiromi, Yano   +6 more
openaire   +2 more sources

Electrochemical Probing of Dopamine Dynamics During Poly(I:C)‐Induced Neuroinflammation

Small
AbstractViruses can infiltrate the central nervous system and contribute to depression, which may include alterations in dopamine (DA) metabolism triggered by immune responses though the specific mechanisms involved remain unclear. Here, an electrochemical system to realize the real‐time dynamic monitoring of DA with high sensitivity is proposed and it
Jian Wang, Qiang Zhou, Yuchan Zhang, Shuang Zhao, Li Li, Zhongyuan Zeng, Jiajia Chen, Yangmingxu Meng, Xianglong Zhao, Tianqi Wang, Zexuan Meng, Haihan Yuan, Jianhua Ran, Guixue Wang, Chen‐zhong Li, Guangchao Zang   +15 more
openaire   +2 more sources

Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation

2014
In this chapter, we describe the technique of electroporation as an efficient method to load primary leukemic cells with the double-stranded RNA (dsRNA) analogue, polyriboinosinic polyribocytidylic acid (poly(I:C)), and detail on the delicate freezing and thawing procedure of primary leukemic cells.Electroporation is a non-viral gene transfer method by
Lion, E., de Winde, C.M., de Winde, C.M., Van Tendeloo, V.F., Smits, E.L.   +4 more
openaire   +3 more sources

The Effect of Actinomycin D on the Lethality of Poly I:C

The Journal of Immunology, 1971
Abstract Poly I:C, a synthetic double-stranded RNA composed of polyinosinic and polycytidylic acids, has become the subject of intense investigation because of its capacity to induce interferon formation and exert antineoplastic activity in experimental animals (1–4).
R E, Pieroni, A E, Bundeally, L, Levine
openaire   +2 more sources

Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections

Archives of Internal Medicine, 1970
The effective control of viral diseases is a difficult problem and necessitates the exercise of opportunism to explore and utilize all possible approaches. Certain of the viruses for which there is a single or few serotypes lend themselves well to control by vaccines as, eg, poliomyelitis, measles, mumps, rubella, yellow fever, influenza, and smallpox.
openaire   +2 more sources

The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage

Archives of Pharmacal Research, 1994
Macrophages play an important role in defense against virus infection by intrinsic resistance and by extrinsic resistance. Since interferon-induced enzymes which are 2'-5' oligoadenylate synthetase and P1/eIF-2 protein kinase have been shown to be involved in the inhibition of viral replication, I examined the mechanism by which poly I:C, an interferon
openaire   +2 more sources

VEGF, Poly(i:C), and Innate Immune Response

American Journal of Respiratory and Critical Care Medicine, 2012
Laimute, Taraseviciene-Stewart, Norbert F, Voelkel   +1 more
openaire   +2 more sources