Results 101 to 110 of about 58,232 (298)
Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication
Cell Reports, 2019 Summary: Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and ...
Patrick M. Tate +2 more
doaj +1 more source
Chemicals bacteria encounter at the infection site could shape their stress and antibiotic responses; such effects are typically undetected under standard lab conditions.
Omar M. El-Halfawy (8414889) +2 more
core +1 more source
The Chemical Record, EarlyView.Nickel foam—one material, two faces, and several versatile roles depending on electrolytic conditions. For more than 50 years, nickel foam electrodes have served in electrosynthesis as powerful and readily available electrode materials. Due to their inexpensive nature and easy handling, they have been widely employed.
Rok Narobe +2 more
wiley +1 more source
Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity
Viruses, 2019 Polyamines are small positively-charged molecules abundant in eukaryotic cells that are crucial to RNA virus replication. In eukaryotic cells, polyamines facilitate processes such as transcription, translation, and DNA replication, and viruses similarly ...
Courtney N. Dial +3 more
doaj +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
Functions of polyamine acetylation
, 1987 Acetylation is a means to decrease the net positive charge of the plyamines and thus liberate polyamines from anionic binding sites. The acetyl derivatives can be removed from the cells by transport and catabolism. Intracellular polyamine metabolism can
Nikolaus Seiler
core +1 more source
Nonthermal plasma approaches for combating implant‐associated infections: A compendious review
VIEW, EarlyView.Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe +8 more
wiley +1 more source
PLoS ONE, 2017 Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with ...
Kamyar Zahedi +12 more
doaj +1 more source
Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery.
PLoS BiologyBacterial pathogens utilize the factors of their hosts to infect them, but which factors they exploit remain poorly defined. Here, we show that a pathogenic Salmonella enterica serovar Typhimurium (STm) exploits host polyamines for the functional ...
Tsuyoshi Miki +10 more
doaj +1 more source