Results 121 to 130 of about 65,399 (230)

Synthesis of Polyamine Type Flocculant and Ptoperties in Potable Water Treatment

, 1998
?????? ????????? ????????? ?????? ??????????????? ????????? ????????? ??????????????? ?????????????????? (Alum : Al2(SO4)3) ??? polyaluminum chlorider (PAC) ??? ?????????????????????????????? ????????? ?????? ????????? ????????? ????????? ????????? ??????
Shin, Myung-Chul, Choi, Sang-June, Park, Lee Soon, Lee, Seok-Hun, Shin, June-Ho   +4 more
core  

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma

Cell Death and Disease
Osteosarcoma, the most prevalent malignant bone tumor among adolescents, frequently exhibits limited responsiveness to immunotherapy, a challenge attributed to poorly understood underlying mechanisms.
Jiaming Yu, Chuanxia Zhang, Qinkai Zhang, Bing Lu, Guohao Lu, Chunxiao Zhang, Ru Qiu, Xinyue Wang, Changye Zou, Junjun Chu, Haizhou Li, Wei Zhao   +11 more
doaj   +1 more source

Functional Characterization of the P‐Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters [PDF]

FASEB J
ATP13A3 and ATP13A4 mediate the plasma membrane uptake of the polyamines, putrescine and spermidine, in an ATP‐dependent manner. ATP13A3 is broadly expressed across human tissues, whereas ATP13A4 is expressed at relatively high levels in the brain and lung.
Morimoto H, Yasujima T, Yamasaki M, Yamashiro T, Yuasa H.   +4 more
europepmc   +2 more sources

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging

Amino Acids
Interest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emerging evidence in
Miora Bruna Marielle Ramamonjiharisoa, Sen Liu   +1 more
doaj   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Differences in Polyamine Levels between 'Kyoho,' 'Campbell Early' and 'Muscat Bailey A' Grapes with Differing Features of Berry Drop

, 2002
A comparative study was conducted of berry dropping and changes in polyamine levels in 'Kyoho,' 'Campbell Early' and 'Muscat Bailey A' grapes. Berry dropping occurred first in 'Muscat Bailey A' grapes, peaking 6 days after full bloom.
OGATA, Tsuneo, SHIOZAKI, Shuji, HORIUCHI, Shosaku   +2 more
core