Results 151 to 160 of about 58,232 (298)

Root Structural and Metabolic Plasticity Confers Tolerance to Salinity in Wild Barley Species Grown Under Waterlogging

Plant, Cell &Environment, EarlyView.
ABSTRACT Salinity combined with waterlogging is a major abiotic stress that severely limits crop growth and yield. We investigated species‐specific adaptations to salinity under constant waterlogging conditions in the wild halophytic barleys Hordeum marinum and H. glaucum, compared with the cultivated H. vulgare.
Stanislav Isayenkov, Ljudmilla Borisjuk, Simon Mayer, Alexander Hilo, Dominic Knoch, Tobias Meitzel, Bettina Hause, Yudelsy Antonia Tandron Moya, Hardy Rolletschek, Edgar Peiter, Volodymyr Radchuk   +10 more
wiley   +1 more source

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, EarlyView.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma

Cell Death and Disease
Osteosarcoma, the most prevalent malignant bone tumor among adolescents, frequently exhibits limited responsiveness to immunotherapy, a challenge attributed to poorly understood underlying mechanisms.
Jiaming Yu, Chuanxia Zhang, Qinkai Zhang, Bing Lu, Guohao Lu, Chunxiao Zhang, Ru Qiu, Xinyue Wang, Changye Zou, Junjun Chu, Haizhou Li, Wei Zhao   +11 more
doaj   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Polyamine depletion limits progression of acute leukaemia

Cancer cells are addicted to polyamines, polycations essential for cellular function. While dual targeting of cellular polyamine biosynthesis and polyamine uptake is under clinical investigation in solid cancers, preclinical and clinical studies into its
Azfar, M, Mayoh, C ; https://orcid.org/, Vangheluwe, P, Tanaka, K, Mayoh, C, Haber, M, Somers, K, Burns, MR, Cheung, LC, Lock, RB ; https://orcid.org/, Norris, MD ; https://orcid.org/, Somers, K ; https://orcid.org/, Verhelst, SHL, Bongers, A, Spurling, D, Kotecha, RS, Xiao, L, Guo, X, Ronca, E, Karsa, M, Norris, MD, Lock, RB, Gao, W, Karsa, A, Haber, M ; https://orcid.org/   +24 more
core   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source

Inhibition of chickpea seedling copper amine oxidases by tetraethylenepentamine [PDF]

Copper amine oxidases are important enzymes, which contribute to the regulation of monoand polyamine levels. Each monomer contains one Cu(II) ion and 2,4,5-trihydroxyphenylalanine (TPQ) as cofactors.
اسدی, اسداله, امانی, مجتبی, طلایی, سونیا   +2 more
core  

Microplastics and nanoplastics in water: Improving removal in wastewater treatment plants with alternative coagulants

The Canadian Journal of Chemical Engineering, Volume 104, Issue 7, Page 3744-3757, July 2026.
The contaminant removal performance of a conventional coagulant, alum, and alternative coagulants, aluminium chlorohydrate (ACH) and ACH + pDADMC, are compared in challenging wastewater treatment conditions (pH >7.8). The interactions of each coagulant with a negatively charged surface are depicted based on quartz crystal microbalance with dissipation ...
Sinan Abi Farraj, Mathieu Lapointe, Rafael S. Kurusu, Nathalie Tufenkji   +3 more
wiley   +1 more source