Results 171 to 180 of about 65,399 (230)

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

A Novel Polyamine Oxidase from <i>Kluyveromyces marxianus</i> with Potential for Total Polyamine Determination. [PDF]

BioTech (Basel)
Sergeev EP, Atroshenko DL.
europepmc   +1 more source

Plant Identity Shapes Core Microbiomes on Green Roofs

Environmental Microbiology Reports, Volume 18, Issue 6, December 2026.
Three plant species selected from coal mine spoil heaps using a trait‐based approach were associated with distinct bacterial and fungal microbiome patterns in extensive green roof substrates. Discriminant taxa and differences in predicted metabolic pathways provided complementary taxonomic and functional perspectives on plant‐associated substrate ...
Katarzyna Larysz, Michał Ludynia, Artur Trzebny, Wiktoria Klencz, Natalia Malcherczyk, Edyta Sierka   +5 more
wiley   +1 more source

Peptide‐Linked Bivalent Nanobody Constructs as Positive Allosteric Modulators of the Calcium‐Sensing Receptor

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.
ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour, Charlotte Hagen Skadhauge, Line Juel Rasmussen, Hans Bräuner‐Osborne, Jesper M. Mathiesen, Anders A. Jensen   +5 more
wiley   +1 more source

IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages. [PDF]

J Allergy Clin Immunol
Zhang W, Cheon IS, Pajulas A, Sinn AL, Krishnan MS, Zhang J, Abdelaal AM, Liu X, Jackson KG, Zhang J, Pollok KE, Kloepfer KM, Twigg HL, Gaston B, Teague WG, Sun J, Kaplan MH.   +16 more
europepmc   +1 more source

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

Glia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton, Luis E. Villafuerte, Alejandra P. Garza, Nina Lindemann, Elisa Wider‐Eberspächer, Dunja Bruder, Ildiko R. Dunay   +6 more
wiley   +1 more source

Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila. [PDF]

Amino Acids
Bangash ZR, Matsui H, Ranxhi B, Todi SV, LeWitt PA, Tsou WL.   +5 more
europepmc   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Difluoromethylornithine modulates mutant K-RAS signaling pathways in pancreatic cancer cells. [PDF]

Amino Acids
Chen H, Stringer DE, Cui H, Gerner EW, Ignatenko NA.   +4 more
europepmc   +1 more source

Reduced circulating polyamines in polyendocrine metabolic ovarian syndrome patients and the impact of putrescine on ovarian function and fertility in a murine PMOS model†. [PDF]

Biol Reprod
Das S, Fernandes JRD, Nikhil PT, Narayana S, Shinde G, Mukherjee S, Anand C, Kumari NS, Mohapatra S, Banerjee A.   +9 more
europepmc   +1 more source