Results 41 to 50 of about 44,780 (134)

Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery.

PLoS Biology
Bacterial pathogens utilize the factors of their hosts to infect them, but which factors they exploit remain poorly defined. Here, we show that a pathogenic Salmonella enterica serovar Typhimurium (STm) exploits host polyamines for the functional ...
Tsuyoshi Miki, Takeshi Uemura, Miki Kinoshita, Yuta Ami, Masahiro Ito, Nobuhiko Okada, Takemitsu Furuchi, Shin Kurihara, Takeshi Haneda, Tohru Minamino, Yun-Gi Kim   +10 more
doaj   +1 more source

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.

PLoS ONE, 2017
Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with ...
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R Doherty, Mark A Hall, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleimani   +12 more
doaj   +1 more source

The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma

Molecular Oncology
High‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning.
Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers   +19 more
doaj   +1 more source

Polyamine metabolism and anti-tumor immunity

Frontiers in Immunology
Growing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu, Yan Zeng, Yu-Yang You, Qi-Yue Chen   +3 more
doaj   +1 more source

Dissecting rice polyamine metabolism under controlled long-term drought stress.

PLoS ONE, 2013
A selection of 21 rice cultivars (Oryza sativa L. ssp. indica and japonica) was characterized under moderate long-term drought stress by comprehensive physiological analyses and determination of the contents of polyamines and selected metabolites ...
Phuc Thi Do, Thomas Degenkolbe, Alexander Erban, Arnd G Heyer, Joachim Kopka, Karin I Köhl, Dirk K Hincha, Ellen Zuther   +7 more
doaj   +1 more source

Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma

Discover Oncology
Polyamines, including spermidine, spermine, and putrescine, are polycationic alkylamines in mammalian cells. However, the prognostic impact of polyamine in glioma remains unclear.
Fei Bai, Kexin Zhai, Tiantian Yao, Yuxia Zhou, Yongxiang Zhao, Guanghui Yang   +5 more
doaj   +1 more source

Duplication and diversification of the spermidine/spermine N1-acetyltransferase 1 genes in zebrafish.

PLoS ONE, 2013
Spermidine/spermine N(1)-acetyltransferase 1 (Ssat1) is a key enzyme in the polyamine interconversion pathway, which maintains polyamine homeostasis.
Yi-Chin Lien, Ting-Yu Ou, Yu-Tzu Lin, Po-Chih Kuo, Han-Jia Lin   +4 more
doaj   +1 more source

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages

Smart Medicine
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis.
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
doaj   +1 more source

Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients

Applied Sciences
Polyamines are essential biological compounds that play crucial roles in various physiological processes, including cardiovascular function. This study explored polyamine levels in peripheral blood cells and plasma from patients with acute myocardial ...
José Manuel Rubín, Lorena Suárez, Begoña Cantabrana, Eva Barreiro-Alonso, Ignacio Rodríguez-Uña, Manuel Sánchez   +5 more
doaj   +1 more source

Subtype‐Specific Transcription Factors Affect Polyamine Metabolism and the Tumor Microenvironment in Breast Cancer

Cancer Innovation
Background Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors.
Qi Song, Yixuan Wang, Sen Liu
doaj   +1 more source