Results 61 to 70 of about 63,812 (294)

Mycolicibacterium smegmatis possesses operational agmatinase but contains no detectable polyamines

International Journal of Mycobacteriology, 2020
Background: Polyamines are widespread intracellular molecules able to influence antibiotic susceptibility, but almost nothing is known on their occurrence and physiological role in mycobacteria.
Mikhail Zamakhaev, Ivan Tsyganov, Larisa Nesterova, Anna Akhova, Artem Grigorov, Julia Bespyatykh, Tatyana Azhikina, Alexander Tkachenko, Mikhail Shumkov   +8 more
doaj   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Accelerating Phosphate Transport Across Membranes via Synergistic Chemical‐Electrochemical Carriers

Angewandte Chemie, EarlyView.
A new membrane design principle based on synergistic chemical and electrochemical carriers is proposed to construct an electro‐driven carrier‐conducting membrane for high‐throughput phosphate transport. Monodispersed ferrihydrite nanoparticles embedded within the membrane act as built‐in phosphate carriers, enabling accelerated phosphate migration via ...
Lei Xia, Yangbo Qiu, Qingzhi Liu, Mengjiao Guan, Xi Zhang, Raf Dewil, Jin Shang, Yan Zhao, Bart Van der Bruggen, Chuyang Tang   +9 more
wiley   +2 more sources

Genetically encoded fluorescent reporter for polyamines

Nature Communications
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson’s disease and cancer, driving
Pushkal Sharma, Colin Y. Kim, Heather R. Keys, Shinya Imada, Alex B. Joseph, Luke Ferro, Tenzin Kunchok, Rachel Anderson, Yulin Sun, Ömer H. Yilmaz, Jing-Ke Weng, Ankur Jain   +11 more
doaj   +1 more source

A Cyclodextrin Hydrogel For Polyamine Capturing In Periodontitis Treatment

International Dental Journal
Aim or purpose: Polyamine accumulation exacerbates inflammation and tissue destruction in periodontitis, but its therapeutic potential remains unclear, and this study evaluates a polyamine-scavenging hydrogel for periodontitis inflammation by restoring ...
Simeng Wang, Jianhua Li, Weiwei Zhao
doaj   +1 more source

Polyamines and Cancer

, 2017
This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms of cancer, since this pathway is disrupted in all cancers. It is divided into three main sections. The first explores how the polyamine pathway has been targeted for chemotherapy, starting from the first drug ...
Elisabetta, Damiani, Heather M, Wallace
openaire   +2 more sources

Efficient Adsorption‐Based Direct Air Capture Via Triply Periodic Minimal Surface Architectures

Advanced Science, EarlyView.
Architected triply periodic minimal surface (TPMS) contactors reshape direct air capture by replacing straight‐channel diffusion limits with convection‐enhanced CO2 transport. Chaotic advection thins boundary layers and exposes fast adsorption sites, enabling 70%–75% more fast sites, 114% higher productivity, and 51.8% lower energy consumption than ...
Qingyang Shao, Zhuozhen Gan, Chengcheng Long, Man Zhang, Yihe Miao, Yuehui Li, Xuancan Zhu   +6 more
wiley   +1 more source

Polyamine modified particles [PDF]

, 2005
A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a ...
Kasturi, Sudhir Pai, Roy, Krishnendu
core   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations Objectified (SNO)

Food & Nutrition Research, 2011
Background: Dietary polyamines have been shown to give a significant contribution to the body pool of polyamines. Knowing the levels of polyamines (putrescine, spermidine, and spermine) in different foods and the contribution of daily food choice to ...
Mohamed Atiya Ali, Eric Poortvliet, Roger Strömberg, Agneta Yngve   +3 more
doaj   +1 more source