Results 61 to 70 of about 44,333 (244)
Opposing Roles for ATP13A2 and ATP13A3 in Breast Cancer Subtype-Specific Polyamine Homeostasis
BiomoleculesPolyamine homeostasis is essential for normal cellular function and is maintained through coordinated regulation of polyamine biosynthesis, catabolism, and transport.
Emily Meeus +3 more
doaj +1 more source
Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]
, 2009 Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Karodia, N, Maurice, HB, Phillips, Roger
core
, 2017 This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms of cancer, since this pathway is disrupted in all cancers. It is divided into three main sections. The first explores how the polyamine pathway has been targeted for chemotherapy, starting from the first drug ...
Elisabetta, Damiani, Heather M, Wallace
openaire +2 more sources
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Frontiers in ImmunologyImmune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of
Jianyan Pan +3 more
doaj +1 more source
Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants [PDF]
, 1987 Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of ...
Bucher +28 more
core +1 more source
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. [PDF]
, 2016 There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis of the metabolic changes in lungs at the early stage of PH, characterized by increased ...
Black, Stephen M +10 more
core +9 more sources
Porous Carbon Materials for Carbon Dioxide Capture
Carbon Energy, EarlyView.This work aims to address the current status and challenges associated with the regulation of pore structures, as well as the influence of pore structures on CO2 capture. Systematic quantitative analysis of structure–property relationships, combined with machine learning approaches, can effectively evaluate the contributions of structural ...
Zhifu Liu +6 more
wiley +1 more source
Differences in Polyamine Metabolism between Carcinomatous and Uninvolved Human Breast Tissues
The International Journal of Biological Markers, 1986 The polyamine biosynthetic enzymes ODC and SAMDC show higher activity in carcinomatous human breast tissue than in uninvolved tissue of the same breast; the interconversion enzyme PAO shows significantly lower activity in carcinomatous than uninvolved ...
Marta Romano +4 more
doaj +1 more source
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments [PDF]
, 2009 TGases (transglutaminases) are a class of calcium-dependent enzymes that catalyse the interactions between acyl acceptor glutamyl residues and amine donors, potentially making crosslinks between proteins.
Bonner, PLR +4 more
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