Results 61 to 70 of about 58,354 (282)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Polyamine-Mediated Sensitization of Klebsiella pneumoniae to Macrolides through a Dual Mode of Action [PDF]

Chemicals bacteria encounter at the infection site could shape their stress and antibiotic responses; such effects are typically undetected under standard lab conditions.
Omar M. El-Halfawy (8414889), Joshua M. E. Adams (18493867), Peri B. Moulding (18493870)   +2 more
core   +1 more source

Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations Objectified (SNO)

Food & Nutrition Research, 2011
Background: Dietary polyamines have been shown to give a significant contribution to the body pool of polyamines. Knowing the levels of polyamines (putrescine, spermidine, and spermine) in different foods and the contribution of daily food choice to ...
Mohamed Atiya Ali, Eric Poortvliet, Roger Strömberg, Agneta Yngve   +3 more
doaj   +1 more source

Surfactants as a Tool for Coupling Light Into Hydrodynamic Flow: The Influence of Surfactant Hydrophobicity and Head Polarity

Advanced Materials Interfaces, EarlyView.
Reversible light‐induced gradients at solid–liquid interfaces enable controllable interfacial transport via light‐driven diffusioosmosis. We demonstrate directed particle manipulation based on dynamically generated concentration gradients. The mechanism is broadly applicable to cationic, anionic, and non‐ionic surfactants with varying hydrophobicity ...
Maren Umlandt, David Feldmann, Nino Lomadze, Svetlana Santer   +3 more
wiley   +1 more source

Structure-activity relationship of polyamine conjugates for uptake via polyamine transport system [PDF]

, 2019
High toxicity of anticancer drugs led to development of targeted drug delivery directly to the specific organs. Polyamine transport system (PTS) of mammalian cells is one of the targets for a cell-selective drug delivery of polyamine-drug conjugates into
Sadeghi-aliabadi, Hojjat, Saghaie, Lotfollah, Nazifi, Mohamad Reza, Fassihi, Afshin   +3 more
core   +1 more source

Modulation of polyamine catabolism in pea seedlings by calcium during salinity stress

Plant Protection Science, 2012
The relation of polyamine catabolism in the response of Pisum sativum to salinity stress was investigated. Pea seedlings were grown in increasing concentrations of Na+ or K+ or at different concentration ratios of these ions. We studied the effect of Ca2+
Jana Piterková, Lenka Luhová, Ludmila Zajoncová, Marek Šebela, Marek Petřivalský   +4 more
doaj   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Functions of polyamine acetylation [PDF]

, 1987
Acetylation is a means to decrease the net positive charge of the plyamines and thus liberate polyamines from anionic binding sites. The acetyl derivatives can be removed from the cells by transport and catabolism. Intracellular polyamine metabolism can
Nikolaus Seiler
core   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

POLYAMINE OXIDATION-ASSOCIATED DAMAGE: FRIEND OR FOE? IMPLICATIONS FOR POLYAMINE THERAPEUTIC INTERVENTIONS [PDF]

, 2021
Polyamines are polycationic alkylamines involved in many cellular functions, and as a result their homeostasis is tightly regulated through coordinated biosynthesis, catabolism, and transport. The oxidation of polyamines occurs during their catabolism as
Holbert, Cassandra
core