Results 71 to 80 of about 65,399 (230)

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

A Drosophila Model To Identify Polyamine-Drug Conjugates That Target The Polyamine Transporter In An Intact Epithelium

, 2008
Polyamine transport is elevated in many tumor types, suggesting that toxic polyamine - drug conjugates could be targeted to cancer cells via the polyamine transporter (PAT). We have previously reported the use of Chinese hamster ovary (CHO) cells and its
Kaur, Navneet, Tsen, Chung, Iltis, Mark, Bayer, Cynthia, Delcros, Jean Guy   +4 more
core   +2 more sources

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

PLoS ONE, 2017
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers.
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero   +6 more
doaj   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma

Molecular Oncology
High‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning.
Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers   +19 more
doaj   +1 more source

Supplementary Material for: The Amino Acid-Polyamine-Organocation Superfamily

, 2017
The amino acid-polyamine-organocation (APC) superfamily has been shown to include five recognized families, four of which are specific for amino acids and their derivatives.
Wong F.H. (4132888), Saier, Jr. M.H. (4132894), Day J.L. (4132903), Reddy V. (4132891), Wakabayashi S.T. (4132906), Chen J.S. (4132897), Shlykov M.A. (4132900)   +6 more
core   +1 more source

Nitrogen‐Stitched rGO/Graphite Bilayer Anodes for Accelerated Li‐Ion Transport and Interfacial Charge Regulation

Carbon Energy, EarlyView.
Nitrogen‐stitched rGO forms an active charge‐regulating bilayer on graphite that pre‐adsorbs, guides, and delivers Li+ into the lattice. This adsorption–migration–diffusion pathway accelerates Li+ transport, stabilizes the interface, and enables fast‐charging performance beyond conventional graphite limits.
Hojun Moon, Rama Krishna Chava, Kotesh Kumar Mandari, Annamalai Raja, Younghwan Im, Jeeyoung Yoo, Misook Kang   +6 more
wiley   +1 more source

ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape

Cell Death and Disease
Metabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Han Tao, Xiaojun Wang, Zhiyi Hu, Yiran Li, Mengwen Kong, Yeli Sun, Kun Gao, Xiaoping Wan   +7 more
doaj   +1 more source

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.

PLoS ONE, 2017
Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with ...
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R Doherty, Mark A Hall, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleimani   +12 more
doaj   +1 more source

Polymer Molecular Interface Engineering—Enhanced Cu‐Based Catalysts for the CO2 Electroreduction Reaction

Carbon Energy, EarlyView.
This review highlights polymer‐mediated interfacial engineering strategies for Cu‐based electrocatalysts toward enhanced CO2RR, including steering the electronic structure of Cu, enhancing CO2 adsorption and activation, regulating the reaction microenvironment, constructing a molecular protective layer, and stabilizing the key intermediate.
Haoquan Peng, Xinyi Tan, Yalin Xie, Jianren Wang, Zhourong Xiao, Ailing Song, Desong Wang, Liming Dai   +7 more
wiley   +1 more source