Results 71 to 80 of about 44,333 (244)

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]

, 2019
Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria, Buchert, Ralph, Flöel, Agnes, Grittner, Ulrike, Hetzer, Stefan, Horn, Nora, Kopp, Ute, Köbe, Theresa, Lange, Catharina, Madeo, Frank, Maglione, Marta, Mai, Knut, Michael, Eva, Märschenz, Stefanie, Schmitz, Dietmar, Schwarz, Claudia, Sigrist, Stephan J., Stekovic, Slaven, Wirth, Miranka   +18 more
core   +2 more sources

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci

Scientific Reports, 2022
Polyamines are small cationic molecules that have been linked to various cellular processes including replication, translation, stress response and recently, capsule regulation in Streptococcus pneumoniae (Spn, pneumococcus).
Moses B. Ayoola, Leslie A. Shack, Jung Hwa Lee, Juhyeon Lim, Hyungjin Eoh, Edwin Swiatlo, Otto Phanstiel, Bindu Nanduri   +7 more
doaj   +1 more source

Medium alkalization due to carbon metabolism is largely responsible for inhibition of bacterial growth by Vibrio cholerae supernatants [PDF]

, 2017
Vibrio cholerae is the causative agent of the diarrheal disease cholera. Many Vibrio species secrete antimicrobial factors, though the identity of such a factor has not been determined for any V. cholerae strain.
Becker, Miranda
core   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Frontiers in Pharmacology, 2020
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras, Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal, Andrés Rivera-Dictter, Antonia Martin-Martin, Rafael A. Burgos, Pablo Alarcon, Rodrigo López-Muñoz   +9 more
doaj   +1 more source

Abnormal flowers and pattern formation in floral [PDF]

, 1989
“From our acquaintance with this abnormal enabled to unveil the secrets that normal us, and to see distinctly what, from the regular we can only infer.” - J. W.
Bowman, John L., Meyerowitz, Elliot M., Smyth, David R.   +2 more
core  

The Multifaceted Activity of the VirF Regulatory Protein in the Shigella Lifestyle [PDF]

, 2016
Shigella is a highly adapted human pathogen, mainly found in the developing world and causing a severe enteric syndrome. The highly sophisticated infectious strategy of Shigella banks on the capacity to invade the intestinal epithelial barrier and cause ...
Colonna, Bianca, DI MARTINO, MARIA LETIZIA, Falconi, Maurizio, Micheli, Gioacchino, Prosseda, Gianni   +4 more
core   +3 more sources

Helical polyamines

Chemical Science
The first report on isotactic poly(propylene imine) and its stereoblock copolymers prepared by living anionic polymerization.
Daniël Hagedoorn, Sandra Michel-Souzy, Bartłomiej Gostyński, Hubert Gojzewski, Piotr Paneth, Jeroen J. L. M. Cornelissen, Frederik R. Wurm   +6 more
openaire   +3 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source