Results 71 to 80 of about 58,354 (282)
The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. [PDF]
, 2021 Deregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development.
Petrie, K +22 more
core +1 more source
Frontiers in ImmunologyImmune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of
Jianyan Pan +3 more
doaj +1 more source
, 2017 This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms of cancer, since this pathway is disrupted in all cancers. It is divided into three main sections. The first explores how the polyamine pathway has been targeted for chemotherapy, starting from the first drug ...
Elisabetta, Damiani, Heather M, Wallace
openaire +2 more sources
Polyamine Uptake, Kinetics, and Competition among Polyamines and between Polyamines and Inorganic Cations [PDF]
Plant Physiology, 1986 Polyamine uptake, the kinetics of this uptake, and the competition among polyamines and between polyamines and inorganic cations were studied in petals of Saintpaulia ionantha Wendl. Uptake experiments using (14)C-labeled polyamines were carried out on single petals, at room temperaure (20 degrees C) and in the light.
R, Pistocchi, N, Bagni, J A, Creus
openaire +2 more sources
Thermally Processable, Transparent, Mechanically Tunable and Robust Bioplastics From Wastepaper
Advanced Science, EarlyView.Unlike conventional inefficient or low‐value wastepaper recycling, a directional transformation strategy is employed to convert whole wastepaper into intact bioplastics with tunable mechanical properties in our work. These bioplastics can be processed into flexible bags or rigid containers and exhibit high transparency, water resistance, repairability,
Zhezhe Zhou +10 more
wiley +1 more source
Differences in Polyamine Metabolism between Carcinomatous and Uninvolved Human Breast Tissues
The International Journal of Biological Markers, 1986 The polyamine biosynthetic enzymes ODC and SAMDC show higher activity in carcinomatous human breast tissue than in uninvolved tissue of the same breast; the interconversion enzyme PAO shows significantly lower activity in carcinomatous than uninvolved ...
Marta Romano +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras +9 more
doaj +1 more source
Advanced Science, EarlyView.As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
A perspective of polyamine metabolism [PDF]
, 2003 Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects.
Fraser, Alison V +2 more
core +1 more source
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source