Results 211 to 220 of about 973,687 (259)
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Polyamine metabolism revisited
European Journal of Gastroenterology & Hepatology, 2001The natural polyamines putrescine, spermidine and spermine play an essential role in cell growth and differentiation. Cellular polyamine depletion results in inhibition of growth, whereas its accumulation appears to be toxic. Intracellular levels of polyamines are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and
J L, Urdiales +2 more
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Polyamine metabolism in the Microsporidia
Biochemical Society Transactions, 2003Members of the phylum Microspora are all obligate intracellular parasites. Little is known concerning metabolic pathways in these parasites, some of which pose serious problems in immunocompromised patients. We investigated polyamine metabolism in the systemic pathogen Enterocytozoon cuniculi using intact pre-emergent spores, and cell-free preparations.
C J, Bacchi, N, Yarlett, L M, Weiss
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Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications
Medical Sciences, 2018 The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Ana Lambertos +2 more
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Digestion, 2009
Currently, two major pathways are distinguished along which the polyamines are metabolized: the interconversion pathway and the so-called terminal polyamine catabolism. In vertebrates, the interconversion pathway is a cyclic process which controls polyamine turnover.
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Currently, two major pathways are distinguished along which the polyamines are metabolized: the interconversion pathway and the so-called terminal polyamine catabolism. In vertebrates, the interconversion pathway is a cyclic process which controls polyamine turnover.
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Polyamine metabolism and function in brain
Neurochemistry International, 1981Putrescine, spermidine and spermine are simple alipathic polycations of ubiquitous occurrence. The pathways of biosynthesis and catabolism, and changes of the concentrations of these compounds in brain under various conditions are discussed. The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only ...
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Polyamine Metabolism in Pneumocystis carinii
Journal of Infectious Diseases, 1991Alpha-difluoromethylornithine (DFMO) is being used to treat Pneumocystis carinii pneumonia despite a lack of in vitro evidence supporting its antipneumocystis activity. DFMO is a specific inhibitor of ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis. To investigate polyamine metabolism in P.
G Y, Lipschik, H, Masur, J A, Kovacs
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Polyamine metabolism in epileptic cortex
Epilepsy Research, 1992Polyamine (tissue) concentrations have been studied in hippocampus and temporal neocortex from patients with temporal lobe epilepsy. Depth electrode recordings demonstrated hippocampal origin of the seizures, the temporal neocortex being involved during the discharge propagation.
J, Laschet +3 more
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Polyamine metabolism and cancer prevention
Biochemical Society Transactions, 2007Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (non-steroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines are cellular polycations that are essential for cell growth and are overproduced in cancer ...
F R, Saunders, H M, Wallace
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Polyamine metabolism in filarial worms
Molecular and Biochemical Parasitology, 1987The human and animal filarial parasites Onchocerca volvulus, Dirofilaria immitis, Brugia patei and Litomosoides carinii contained low levels of putrescine but much higher levels of spermidine and spermine as estimated by ion-pair high pressure liquid chromatography; N-acetylated polyamines were present only in minute amounts.
R M, Wittich, H D, Kilian, R D, Walter
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METABOLISM OF POLYAMINES BY STAPHYLOCOCCUS
Journal of Bacteriology, 1962Rosenthal, Sanford M. (National Institute of Arthritis and Metabolic Diseases, Bethesda, Md.) and Donald T. Dubin . Metabolism of polyamines by Staphylococcus . J. Bacteriol. 84: 859–863.
S M, ROSENTHAL, D T, DUBIN
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