Results 221 to 230 of about 973,687 (259)
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Polyamine metabolism and virus replication
Biochemical Society Transactions, 1985It has become apparent during the past two decades that the vital functions of eukaryotic cells are intimately associated with the synthesis of the polyamines, spermidine and spermine (Pegg & McCann, 1982). Many studies using either whole animals or cell cultures have shown marked increases in ornithine decarboxylase (EC 4.1.1.17) in growing organs and
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Effects of dietary polyamines and clofibrate on metabolism of polyamines in the rat
The Journal of Nutritional Biochemistry, 1999The activities of catalase, polyamine oxidase, diamine oxidase, ornithine decarboxylase, and peroxisomal beta-oxidation were assayed in homogenates from liver and small intestinal mucosa of rats which had been fed either a diet very low in polyamines or a diet containing five times the levels of dietary polyamines (putrescine, spermine, and spermidine)
B P, Brodal +3 more
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Polyamine metabolism in myocardial hypertrophy
European Heart Journal, 1982An increase in the polyamine content of the myocardium occurs early after an increased workload is imposed and appears to be concerned with the control of increased protein synthesis. Polyamines have been shown to stimulate RNA synthesis and to increase the transport of amino acids into myocardial cells. The enzyme ornithine decarboxylase mediates the
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Selective regulation of polyamine metabolism with methylated polyamine analogues
Amino Acids, 2013Polyamine metabolism is intimately linked to the physiological state of the cell. Low polyamines levels promote growth cessation, while increased concentrations are often associated with rapid proliferation or cancer. Delicately balanced biosynthesis, catabolism, uptake and excretion are very important for maintaining the intracellular polyamine ...
Tuomo A, Keinänen +4 more
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Polyamine Metabolism and the Hypertrophic Heart
2006Cardiac muscle hypertrophy is one of the most important compensatory responses of the heart to multiple stresses that may be placed on it. If the stress is not relieved, sustained hypertrophy may progress to dysfunction and heart failure. The polyamines putrescine, spermidine, and spermine increase within hours of various types of experimentally ...
Shantz L. M. +1 more
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Polyamines and polyamine-metabolizing enzyme activities in human semen
Clinica Chimica Acta, 1973Abstract The content of polyamines putrescine, spermidine and spermine as well as the activities of some polyamine-metabolizing enzymes have been analyzed from normal and pathological human semen samples. Seminal fluid from semen samples showing no apparent abnormalities in semen analyses contained about 0.2 mM of putrescine, 0.1 mM of spermidine and
J, Jänne +3 more
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Phenolamides: Bridging polyamines to the phenolic metabolism
Phytochemistry, 2010Phenolamides constitute a diverse and quantitatively major group of secondary metabolites resulting from the conjugation of a phenolic moiety with polyamines or with deaminated aromatic aminoacids. This review summarizes their bioactivities and their reported roles in plant development, adaptation and defence compared to those of their polyamine ...
Bassard, J.E. +3 more
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Polyamines in the Context of Metabolic Networks
2017Polyamines (PAs) are essential biomolecules that are known to be involved in the regulation of many plant developmental and growth processes as well as their response to different environmental stimuli. Maintaining the cellular pools of PAs or their metabolic precursors and by-products is critical to accomplish their normal functions.
Wuddineh, Wegi +2 more
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Toxicity of Polyamines and Their Metabolic Products
Chemical Research in Toxicology, 2013Polyamines are ubiquitous and essential components of mammalian cells. They have multiple functions including critical roles in nucleic acid and protein synthesis, gene expression, protein function, protection from oxidative damage, the regulation of ion channels, and maintenance of the structure of cellular macromolecules.
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Polyamine Metabolism III: Urinary Acetyl Polyamines in Human Cancer
Journal of Pharmaceutical Sciences, 1978Polyamine levels were determined by high-pressure liquid chromatography in the unhydrolyzed 24-hr urine obtained from 15 cancer patients and nine normal subjects. N1-Acetylspermine, N4-acetylspermine, N4-acetylspermidine, and N-(3-aminopropyl)acetamide were not detected in any samples.
M M, Abdel-Monem, K, Ohno
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