Results 171 to 180 of about 29,556 (259)

Polyamine homeostasis in Caenorhabditis elegans relies primarily on transport. [PDF]

Cell Rep
Chang C, Jain A.
europepmc   +1 more source

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study

Aging Cell, Volume 25, Issue 6, June 2026.
Can we boost vaccine responses in older adults? In a double‐blind, randomised, placebo‐controlled pilot study (n = 40, > 65 years), spermidine supplementation (6 mg/day, 13 weeks) was safe and significantly improved immune responses following a 3rd SARS‐CoV‐2 vaccine dose.
Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu, Tanaïs Moreau, Sagida Bibi, Lin Luo, Melissa Govender, Miles Carroll, Sebastian J. Hofer, Eisenberg Tobias, Christoph Magnes, Loren Kell, Christopher Chung, Yu Deng, Aneesha Bhandari, Lucy Garner, Thomas Conrad, Liye Chen, Barbara Kronsteiner‐Dobramysl, Susie Dunachie, Owen B. Spiller, Teresa Lambe, Paul Klenerman, Lucy C. Jones, A. Katharina Simon   +25 more
wiley   +1 more source

Polyamine-Related Gene Families Identification and Regulatory Effects on Early Somatic Embryogenesis via Modulating Gene Expressions and Hormone Levels in <i>Ginkgo biloba</i>. [PDF]

Plants (Basel)
Di J, Ge W, Chen Y, Hu Y, Lu Y, Cai H.
europepmc   +1 more source

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

Aging Cell, Volume 25, Issue 6, June 2026.
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li, Yuhong Zhang, Daijun Yu, Jianhua Li, Keda Chen, Lisheng Chu   +5 more
wiley   +1 more source

Synergistic application of taurine and spermidine enhances wheat tolerance to neodymium stress through redox homeostasis, metabolic adjustment, and nutrient regulation. [PDF]

Plant Signal Behav
Iqbal R, Mehmood H, Majeed A, Murtaza G, Rebouh NY, Alotaibi MS, Alotaibi SS, Ullah S, Huseynova A, Ali S.   +9 more
europepmc   +1 more source

Methionine Restriction Extends Yeast Lifespan by Activating Non‐Nitrogen‐Starvation‐Induced Autophagy Through Limiting Methylation of Protein Phosphatase 2A

Aging Cell, Volume 25, Issue 6, June 2026.
Methionine restriction extends yeast replicative and chronological lifespan as a consequence of depletion of S‐adenosylmethionine (SAM). SAM depletion leads to demethylation of PP2A and increased phosphorylation of Npr2 which activates non‐nitrogen‐starvation (NNS) induced autophagy; early methionine restriction is sufficient to activate persistent ...
Kaylah Birmingham, Nina Arslanovic, Thea Grauer, Ignacio Gutierrez, Ujani Chakraborty, Simone Sidoli, Jessica Tyler   +6 more
wiley   +1 more source

The functional roles and mechanisms of polyamines in age-related bone diseases. [PDF]

Cell Mol Life Sci
Zhang J, Cai C, Zhang Y, Luo C, Huo S, Wang K, Shi C, Liu J, Xu G.   +8 more
europepmc   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer. [PDF]

Cancer Res
Kumar R, Jonnatan S, Sanin DE, Vakkala V, Kadam A, Kumar S, Rosen DM, Dalrymple SL, Zhao L, Foley JR, Holbert CE, Nwafor A, Kittane S, Penner E, Apostolova P, Warner S, Dang CV, Toska E, Thompson EA, Isaacs JT, De Marzo AM, Brennen WN, Pearce EL, Stewart TM, Casero RA, Denmeade SR, Sena LA.   +26 more
europepmc   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source