Results 181 to 190 of about 29,556 (259)

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

open access: yesNeuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros   +6 more
wiley   +1 more source

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology

open access: yesPediatric Allergy and Immunology, Volume 37, Issue 6, June 2026.
This graphical abstract illustrates the conceptual framework linking rare and common diseases in pediatric allergy and immunology through precision medicine. On the left, rare conditions such as inborn errors of immunity and primary atopic disorders represent well‐defined monogenic models that reveal fundamental mechanisms of immune dysregulation.
Riccardo Castagnoli   +26 more
wiley   +1 more source

Polyamine-dependent metabolic shielding regulates alternative splicing. [PDF]

open access: yesNature
Zabala-Letona A   +51 more
europepmc   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3597-3615, June 2026.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro   +4 more
wiley   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar   +7 more
wiley   +1 more source

Natural Variations in the Activity of Hydroxycinnamoyl Transferases Promote Accumulation of Metabolites Conferring Rice Resistance

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3803-3820, June 2026.
ABSTRACT Plant‐derived secondary metabolites act as regulators of in planta defence. Plant phenylpropanoid metabolic compounds, including final metabolites such as lignin and flavonoids, and a few intermediate metabolites play critical roles in defence.
Dan Chen   +9 more
wiley   +1 more source

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