Results 11 to 20 of about 108,919 (320)
Frontiers in Nutrition, 2019 The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties.
Nelly C. Muñoz-Esparza +15 more
doaj +2 more sources
Promotion of homology-directed DNA repair by polyamines
Nature Communications, 2019 The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-
Chih-Ying Lee +7 more
doaj +2 more sources
Role of Polyamines in Immune Cell Functions
Medical Sciences, 2018 The immune system is remarkably responsive to a myriad of invading microorganisms and provides continuous surveillance against tissue damage and developing tumor cells.
Rebecca S. Hesterberg +2 more
doaj +2 more sources
Polyamines: their significance for maintaining health and contributing to diseases
Cell Communication and Signaling, 2023 Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-translational modification.
Mengjuan Xuan +5 more
semanticscholar +1 more source
Polyamines in Parkinson's Disease: Balancing Between Neurotoxicity and Neuroprotection.
Annual Review of Biochemistry, 2023 The polyamines putrescine, spermidine, and spermine are abundant polycations of vital importance in mammalian cells. Their cellular levels are tightly regulated by degradation and synthesis, as well as by uptake and export.
Stephanie Vrijsen +4 more
semanticscholar +1 more source
Medical Science, 2022 The polyamines spermidine and spermine are positively charged aliphatic molecules. They are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein and nucleic acid interactions, oxidative balance, and cell ...
K. Zahedi +2 more
semanticscholar +1 more source
Metabolism and function of polyamines in cancer progression.
Cancer Letters, 2021 Polyamines are essential for the proliferation, differentiation, and development of eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and are low-molecular-weight, organic polycations with more than two amino groups ...
Ita Novita Sari +5 more
semanticscholar +1 more source
Plant Science, 2021 Polyamines play a fundamental role in the functioning of all cells. Their regulatory role in plant development, their function under stress conditions, and their metabolism have been well documented as regards both synthesis and catabolism in an ...
Magda Pál +3 more
semanticscholar +1 more source
Science Advances, 2021 Glioma-associated myeloid cells generate polyamines to survive and function within the acidic tumor microenvironment. Glioblastoma is characterized by the robust infiltration of immunosuppressive tumor-associated myeloid cells (TAMCs).
J. Miska +18 more
semanticscholar +1 more source
Polyamines and Kynurenines at the Intersection of Immune Modulation.
Trends in immunology, 2020 Polyamines (i.e., putrescine, spermidine, and spermine) are bioactive polycations capable of binding nucleic acids and proteins and modulating signaling pathways.
E. Proietti +3 more
semanticscholar +1 more source