Results 41 to 50 of about 1,317 (206)
Iodine/Palladium Approaches to the Synthesis of Polyheterocyclic Compounds [PDF]
The Journal of Organic Chemistry, 2010 A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I(2) or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently ...
Saurabh, Mehta, Richard C, Larock
openaire +2 more sources
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis. [PDF]
, 2014 The synthesis of diverse three-dimensional libraries has become of paramount importance for obtaining better leads for drug discovery. Such libraries are predicted to fare better than traditional compound collections in phenotypic screens and against ...
Alza, Esther +8 more
core +1 more source
Molecules, 2018 A series of eight new 5-aryl-benzo[f][1,7]naphthyridines were synthesized in 17 to 64% overall yields via an improved MW-assisted cascade-like one pot process (Ugi–three component reaction/intramolecular aza-Diels-Alder cycloaddition) coupled to an
Óscar Vázquez-Vera +8 more
doaj +1 more source
Novel magneto-optic behaviour from a polysquaraine [PDF]
, 2013 Copyright © 2013 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Synthetic Metals. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other ...
Lynch, Daniel E. +3 more
core +1 more source
Multicomponent reactions in diverse heterocycles synthesis and medicinal chemistry [PDF]
, 2022 The aim of this dissertation is to discuss new protein-protein interaction target, to apply multicomponent reaction chemistry on N-heterocycle compound synthesis for medicinal chemistry and to exploit the novel scaffold modulators for malaria and cancer ...
Zhang, Bidong
core +1 more source
Tris(pentafluorophenyl)borane and beyond: modern advances in borylation chemistry [PDF]
, 2017 As main-group chemistry, in particular boron chemistry, has expanded and developed over the past 20 years, one reagent has risen to prominence as well.
James R. Lawson +3 more
core +2 more sources
, 2004 Dynamics of regio-regulated Poly(4-methylthiazole-2,5-diyl) [HH-P4MeTz] was inves tigated by solid-state 1H, 2D, 13C NMR spectroscopies, and differential scanning calorimetry(DSC) measurements.
D. C. Ailion +21 more
core +1 more source
Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.The demand for robust antiviral approaches is underscored by the continued COVID‐19 spread. SARS‐CoV‐2 Nsp1, highly conserved among SARS‐CoV‐2 variants, plays a pivotal role in controlling host protein expression and viral RNA translation. A small‐molecule Nsp1 inhibitor exhibited antiviral activity against various sarbecoviruses, signifying a ...
Wan Gi Byun +7 more
wiley +2 more sources
1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions
, 2010 International audienceModern organic synthesis focuses on the discovery and the development of stereoselective multiple bond-forming transformations allowing the creation of several covalent bonds in a single operation.
Bonne, Damien +3 more
core +4 more sources
One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures
Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.One‐pot three‐component coupling of pyridine‐2‐acetonitrile, N‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU allowed facile access to a novel indolizine‐pyrrolodiazepine hybrid structure via a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation process enabling sequential construction of two ...
Sunhee Lee, Seonghyeon Nam, Ikyon Kim
wiley +1 more source