Results 41 to 50 of about 888 (170)

Broad‐Spectrum Antiviral Agents against SARS‐CoV‐2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction

Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.
The demand for robust antiviral approaches is underscored by the continued COVID‐19 spread. SARS‐CoV‐2 Nsp1, highly conserved among SARS‐CoV‐2 variants, plays a pivotal role in controlling host protein expression and viral RNA translation. A small‐molecule Nsp1 inhibitor exhibited antiviral activity against various sarbecoviruses, signifying a ...
Wan Gi Byun, Minha Lee, Meehyun Ko, Ji Hyae Lee, Sihyeong Yi, JinAh Lee, Seungtaek Kim, Seung Bum Park   +7 more
wiley   +2 more sources

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization

Beilstein Journal of Organic Chemistry, 2012
A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π- cyclization. The strategy involves the introduction of an amino
Piyush K. Agarwal, Meena D. Dathi, Mohammad Saifuddin, Bijoy Kundu   +3 more
doaj   +1 more source

One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures

Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
One‐pot three‐component coupling of pyridine‐2‐acetonitrile, N‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU allowed facile access to a novel indolizine‐pyrrolodiazepine hybrid structure via a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation process enabling sequential construction of two ...
Sunhee Lee, Seonghyeon Nam, Ikyon Kim
wiley   +1 more source

γ‐Terpinene: Biorenewable Reductant for the Molybdenum‐Catalyzed Reduction of Sulfoxides, N‐Oxides and Nitroarenes

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract A molybdenum‐catalyzed deoxygenation of sulfoxides, pyridine and quinoline N‐oxides, N‐hydroxybenzotriazoles, as well as the reduction of nitroarenes to anilines, has been developed using monocyclic terpenes such as γ‐terpinene as an environmentally benign hydrogen surrogate.
Raquel Hernández‐Ruiz, Marta Solas, Samuel Suárez‐Pantiga, María R. Pedrosa, Roberto Sanz   +4 more
wiley   +1 more source

Polyheterocyclic Systems Incorporating Pyrazole, Thiophene, Thiazole, and Thiadiazole Moieties.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kamal M. Dawood, Eman A. Ragab, Ahmad M. Farag   +2 more
openaire   +1 more source

Molybdenum-Catalyzed Synthesis of Nitrogenated Polyheterocycles from Nitroarenes and Glycols with Reuse of Waste Reduction By-product [PDF]

, 2017
A novel domino reduction/imine formation/intramolecular cyclization/oxidation for the efficient synthesis of pyrrolo(indolo)[1,2-a]quinoxalines and pyrrolo(indolo)[3,2-c]-quinolines from readily available nitrobenzenes and glycols is reported.
Arnáiz García, Francisco Javier, Fernández Rodríguez, Manuel A., Pedrosa Sáez, María de los Remedios, Rubio Presa, Rubén, Sanz Díez, Roberto   +4 more
core   +1 more source

Palladium‐Catalyzed [3+2+2] Cycloaddition Between Carbonyl‐Tethered Alkylidenecyclopropanes and Isocyanates

Helvetica Chimica Acta, Volume 108, Issue 5, May 2025.
Abstract Carbonyl‐tethered alkylidenecyclopropanes can react with aryl isocyanates in presence of Pd(0)‐phosphoramidite catalysts to give seven‐membered heterobicyclic products in a formal [3+2+2] cycloaddition process. The reaction involves the formation of a palladium π‐allyl complex intermediate (A), which behaves as a formal 1,5‐dipole, and can be ...
Ricardo Rodiño, Jose L. Mascareñas, Fernando López   +2 more
wiley   +1 more source

Ortho‐Quinone Methide Driven Synthesis of New O,N‐ or N,N‐Heterocycles

ChemistryOpen, 2019
To synthesize functionalized Mannich bases that can serve two different types of ortho‐quinone methide (o‐QM) intermediates, 2‐naphthol and 6‐hydroxyquinoline were reacted with salicylic aldehyde in the presence of morpholine.
Dr. István Szatmári, Khadija Belasri, Dr. Matthias Heydenreich, Dr. Andreas Koch, Prof. Dr. Erich Kleinpeter, Prof. Dr. Ferenc Fülöp   +5 more
doaj   +1 more source

Synthesis and optoelectronic properties of new ethynylated pyrazine derivatives [PDF]

, 2003
Several diaryleneethynylpyrazine derivatives, in which the pyrazine unit is electron-deficient, have been synthesised using Sonogashira palladium-catalysed cross-coupling reactions.
Zhao, Liang
core