Results 1 to 10 of about 729 (148)

Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. [PDF]

J Exp Med, 2006
Neutrophils play a central role in host defense, inflammation, and tissue injury. Recent findings indicate a novel role for polyisoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils. The relationship between PIPPs and neutrophil early activating signals, such as phosphoinositides, has not been previously determined.
Bonnans C, Fukunaga K, Keledjian R, Petasis NA, Levy BD.   +4 more
europepmc   +10 more sources

Lipopolysaccharide Is a 4‑Aminoarabinose Donor to Exogenous Polyisoprenyl Phosphates through the Reverse Reaction of the Enzyme ArnT [PDF]

ACS Omega, 2021
Modification of the lipid A portion of LPS with cationic monosaccharides provides resistance to polymyxins, which are often employed as a last resort to treat multidrug-resistant bacterial infections. Here, we describe the use of fluorescent polyisoprenoids, liquid chromatography-mass spectrometry, and bacterial genetics to probe the activity of ...
Beth A. Scarbrough, Colleen R. Eade, Amanda J. Reid, Tiffany C. Williams, Jerry M. Troutman   +4 more
doaj   +6 more sources

Polyisoprenyl phosphates: natural antiinflammatory lipid signals. [PDF]

Cell Mol Life Sci, 2002
Lipoxins (LX) and aspirin-triggered 15-epimer LX are leukocyte-derived eicosanoids generated during host defense that serve as down-regulatory signals. The specific intracellular events that govern cellular responses to inhibitory extracellular signals are of wide interest in order to understand pivotal intracellular events in diseases characterized by
Levy BD, Serhan CN.
europepmc   +5 more sources

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. [PDF]

Br J Pharmacol, 2005
Leukocyte production of reactive oxygen species (ROS) is an essential component of the antimicrobial armament mounted during host defense, but when released to the extracellular milieu ROS can also injure host tissues and provoke inflammation. Polyisoprenyl phosphates (PIPPs) are constituents of human leukocyte membranes that regulate pivotal ...
Levy BD, Hickey L, Morris AJ, Larvie M, Keledjian R, Petasis NA, Bannenberg G, Serhan CN.   +7 more
europepmc   +5 more sources

Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis [PDF]

Nature Communications, 2016
Abstract The attachment of a sugar to a hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. The enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate mannose synthase (DPMS), which generates the mannose donor for ...
Chiara Ardiccioni, Oliver B. Clarke, David Tomasek, Habon A. Issa, Desiree C. von Alpen, Heather L. Pond, Surajit Banerjee, Kanagalaghatta R. Rajashankar, Qun Liu, Ziqiang Guan, Chijun Li, Brian Kloss, Renato Bruni, Edda Kloppmann, Burkhard Rost, M. Chiara Manzini, Lawrence Shapiro, Filippo Mancia   +17 more
core   +7 more sources

Polyisoprenyl phosphate specificity of UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli [PDF]

Glycobiology, 1997
N-Acetyl-D-glucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und), an intermediate in the biosynthesis of the enterobacterial common antigen in E.coli and some O-antigen chains in gram-negative bacteria, is formed by the transfer of GlcNAc 1-P from UDP-GlcNAc to Und-P, analogous to the reaction forming GlcNAc-P-P-dolichol (GlcNAc-P-P-Dol) in mammalian
Jeffrey S. Rush, P D Rick, Charles J. Waechter   +2 more
openalex   +3 more sources

Dolichyl phosphate metabolism in brain. Developmental increase in polyisoprenyl phosphate phosphatase activity.

Journal of Biological Chemistry, 1985
The enzymatic dephosphorylation of endogenous and exogenous dolichyl phosphate (Dol-P) by membrane preparations from calf brain has been reported previously (Burton, W.A., Scher, M.G., and Waechter, C. J. (1981) Arch. Biochem. Biophys. 208, 409-417). The study presented here shows that polyisoprenyl phosphate phosphatase activity increases with age in ...
Malka G. Scher, Carlota Sumbilla, Charles J. Waechter   +2 more
openalex   +3 more sources

Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family [PDF]

Scientific Reports, 2015
AbstractWcaJ is an Escherichia coli membrane enzyme catalysing the biosynthesis of undecaprenyl-diphosphate-glucose, the first step in the assembly of colanic acid exopolysaccharide. WcaJ belongs to a large family of polyisoprenyl-phosphate hexose-1-phosphate transferases (PHPTs) sharing a similar predicted topology consisting of an N-terminal domain ...
Sarah E. Furlong, Amy E. Ford, Lorena Albarnez-Rodriguez, Miguel A. Valvano   +3 more
openalex   +5 more sources

The synthesis and chemical properties of polyisoprenyl beta-D-mannopyranosyl phosphates.

Journal of Biological Chemistry, 1975
2,3,4,6-Tetra-O-acetyl-beta-D-mannopyranosyl phosphate, free of the alpha anomer, was coupled with citronellol and dolichol in the presence of triisopropylbenzenesulfonyl chloride to give, after chromatographic purification and deacetylation, the respective polyisoprenyl beta-D-mannopyranosyl phosphates.
CD Warren, IY Liu, Annete Herscovics, RW Jeanloz   +3 more
openalex   +3 more sources

Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferase [PDF]

Protein Science, 2012
AbstractPolyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferases (PNPTs) constitute a family of eukaryotic and prokaryotic membrane proteins that catalyze the transfer of a sugar‐1‐phosphate to a phosphoisoprenyl lipid carrier. All PNPT members share a highly conserved 213‐Valine‐Phenylalanine‐Methionine‐Glycine‐Aspartic acid‐217 (VFMGD ...
Sarah E. Furlong, Miguel A. Valvano
openalex   +4 more sources