Results 21 to 30 of about 729 (148)

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria. [PDF]

Nat Commun
In Gram-negative bacteria, the enzymatic modification of Lipid A with aminoarabinose (L-Ara4N) leads to resistance against polymyxin antibiotics and cationic antimicrobial peptides.
Ashraf KU, Bunoro-Batista M, Ansell TB, Punetha A, Rosario-Garrido S, Firlar E, Kaelber JT, Stansfeld PJ, Petrou VI.   +8 more
europepmc   +3 more sources

Identification of the Wzx flippase, Wzy polymerase and sugar‐modifying enzymes for spore coat polysaccharide biosynthesis in Myxococcus xanthus

Molecular Microbiology, Volume 113, Issue 6, Page 1189-1208, June 2020., 2020
Myxococcus xanthus differentiates to environmentally resistant spores in response to various stresses. Resistance is provided by the spore coat polysaccharide that is synthesised by the ExoA‐I proteins, which make up an incomplete Wzx/Wzy pathway for polysaccharide synthesis and export. Here, we identified the Wzx flippase and Wzy polymerase as well as
María Pérez‐Burgos, Inmaculada García‐Romero, Miguel A. Valvano, Lotte Søgaard Andersen   +3 more
wiley   +1 more source

Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? [PDF]

, 2021
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management.
Bermúdez, Valmore, Chávez-Castillo, Mervin, Cudris-Torres, Lorena, De Sanctis, Juan B., Duran, Pablo, Garrido, Bermary, Manzano, Alexander, Ortega, Ángel, Rojas, Milagros, Rojas-Gomez, Diana Marcela, Salazar, Juan, Silva, Aljadis   +11 more
core   +1 more source

Nucleotide Sugars in Chemistry and Biology [PDF]

, 2022
Nucleotide sugars have essential roles in every living creature. They are the building blocks of the biosynthesis of carbohydrates and their conjugates.
Satu Mikkola
core   +1 more source

A widespread family of bacterial cell wall assembly proteins [PDF]

, 2011
Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and ...
Adams, Atilano, Bhavsar, Bouhss, Brown, Brunskill, Bunkoczi, Carballido-Lopez, Christopher N Hoyland, Cieslewicz, Claessen, Cleland, Daniel, D‧Elia, D‧Elia, D‧Elia, Emsley, Evans, Figge, Formstone, Formstone, Foster, Glaser, Graumann, Hanson, Harwood, Henriques, Hu, Hübscher, Hübscher, Ishikawa, Jeff Errington, Jon Marles-Wright, Jones, Kawai, Kawai, Kruse, Kuwana, Langer, Lassila, Latge, Lazarevic, Lazarevic, Leaver, Leslie, Masayoshi Kuwano, Massidda, McNeil, Morona, Nadja Heinz, Naotake Ogasawara, Neuhaus, Nhat Khai Bui, Pape, Richard A Daniel, Richard J Lewis, Robert M Cleverley, Robyn Emmins, Scheffers, Schirner, Schirner, Sheldrick, Shu Ishikawa, Slovak, Soldo, Strahl, Swoboda, Swoboda, Tomasz, Vats, Waldemar Vollmer, Wei, Weidenmaier, Wolters, Wu, Yokoyama, Yoshikazu Kawai, Young   +77 more
core   +1 more source

Francisella tularensis Schu S4 lipopolysaccharide core sugar and o-antigen mutants are attenuated in a mouse model of tularemia [PDF]

, 2014
The virulence factors mediating Francisella pathogenesis are being investigated, with an emphasis on understanding how the organism evades innate immunity mechanisms.
Apicella, Michael A, Gibson, Bradford W, Jones, Bradley D, Lindemann, Stephen R, Meyerholz, David K, Post, Deborah M.B., Rasmussen, Jed A   +6 more
core   +2 more sources

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria, Ventura, Valeria Victoria   +1 more
core   +1 more source

Dolichyl-phosphomannose synthase from the Archae Thermoplasma acidophilum [PDF]

, 1996
Archae (formerly Archaebacteria) comprise an entire kingdom of organisms placed halfway between prokaryotes and eucaryotes in evolution, This class of organisms lacks murein cell wall and is devoid of organelles, yet Archae synthesize and export N-linked
Laine, Roger A., Zhu, Betty C.R.
core   +2 more sources

Identification of the lipopolysaccharide O‐antigen biosynthesis priming enzyme and the O‐antigen ligase in Myxococcus xanthus: critical role of LPS O‐antigen in motility and development

Molecular Microbiology, Volume 112, Issue 4, Page 1178-1198, October 2019., 2019
Myxococcus xanthus displays several social behaviors involving cell–cell contacts. To understand the role of the lipopolysaccharide (LPS) in these behaviors, we identified key enzymes involved in O‐antigen and LPS biosynthesis: the polyisoprenyl‐phosphate hexose‐1‐phosphate transferase, responsible for priming O‐antigen synthesis and the O‐antigen ...
María Pérez‐Burgos, Inmaculada García‐Romero, Jana Jung, Miguel A. Valvano, Lotte Søgaard‐Andersen   +4 more
wiley   +1 more source

The Molecular Mechanism of \u3cem\u3eN\u3c/em\u3e-Acetylglucosamine Side-Chain Attachment to the Lancefield Group A Carbohydrate in \u3cem\u3eStreptococcus pyogenes\u3c/em\u3e [PDF]

, 2017
In many Lactobacillales species (i.e. lactic acid bacteria), peptidoglycan is decorated by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape and also represent key antigenic determinants.
Chen, Jing, Deng, Pan, Edgar, Rebecca J., Korotkov, Konstantin V., Korotkova, Natalia, Morris, Andrew J., Rush, Jeffrey, van Sorge, Nina M., Zhu, Haining   +8 more
core   +2 more sources