Results 11 to 20 of about 31,758 (236)
Synthetic biology of polyketide synthases [PDF]
Journal of Industrial Microbiology and Biotechnology, 2018 Abstract Complex reduced polyketides represent the largest class of natural products that have applications in medicine, agriculture, and animal health. This structurally diverse class of compounds shares a common methodology of biosynthesis employing modular enzyme systems called polyketide synthases (PKSs).
Yuzawa, Satoshi +3 more
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Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]
Applied Microbiology and Biotechnology, 2015 Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
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Engineering Polyketide Synthases [PDF]
The Scientific World JOURNAL, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
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Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]
, 2009 OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali +4 more
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Cleaning up Polyketide Synthases
Chemistry & Biology, 2012 Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis,
Kwan, Jason C., Schmidt, Eric W.
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Chemoinformatic-guided engineering of polyketide synthases [PDF]
Journal of the American Chemical Society, 2019 AbstractPolyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated β-carbon through a reductive loop exchange.
Amin Zargar +25 more
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Communications Biology, 2022 Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.
Yuanyuan Feng +5 more
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Polyketide Synthase Modules Redefined [PDF]
Angewandte Chemie International Edition, 2017 Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
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Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata. [PDF]
PLoS ONE, 2012 Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins.
Debjani Saha +7 more
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Don't Classify Polyketide Synthases [PDF]
Chemistry & Biology, 2004 Polyketide synthases are intensively studied as metabolite factories generating diverse biologically active natural products. Contrary to their current classification as different "types," there is now a growing body of evidence illustrating that nature realized limitless transitional stages during evolution.
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