Results 21 to 30 of about 31,758 (236)
Manipulating polyketide stereochemistry by exchange of polyketide synthase modules
Chemical Communications, 2020 Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo +3 more
openaire +4 more sources
BMC Biotechnology, 2019 Background Aspergillus oryzae, a useful industrial filamentous fungus, produces limited varieties of secondary metabolites, such as kojic acid. Thus, for the production of valuable secondary metabolites by genetic engineering, the species is considered a
Koichi Tamano +5 more
doaj +1 more source
Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. [PDF]
PLoS ONE, 2009 Polyketides are natural products with a wide range of biological functions and pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by understanding the evolutionary processes that gave rise to the biosynthetic ...
Imke Schmitt, H Thorsten Lumbsch
doaj +1 more source
Frontiers in Plant Science, 2016 Rhododendron dauricum L. produces daurichromenic acid, the anti-HIV meroterpenoid consisting of sesquiterpene and orsellinic acid moieties. To characterize the enzyme responsible for orsellinic acid biosynthesis, a cDNA encoding a novel polyketide ...
Futoshi Taura +9 more
doaj +1 more source
Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis [PDF]
ACS Synthetic Biology, 2023 Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules. Mixing and matching modules from natural PKSs is one of the routes to produce many of these molecules.
Alberto A. Nava +4 more
openaire +4 more sources
Synthetic and Systems Biotechnology, 2022 Piericidins are a large family of bacterial α-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.
Wanlu Li +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2013 Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes.
Stephan Klopries +2 more
doaj +1 more source
Genomic blueprints of sponge-prokaryote symbiosis are shared by low abundant and cultivatable Alphaproteobacteria [PDF]
, 2019 Marine sponges are early-branching, filter-feeding metazoans that usually host complex microbiomes comprised of several, currently uncultivatable symbiotic lineages.
Cox, Cymon +6 more
core +4 more sources
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]
Angewandte Chemie International Edition, 2018 AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A. Meoded +6 more
openaire +3 more sources
Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening [PDF]
, 2003 New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a macroarray cDNA library. The comparison was performed between mRNA populations of embryos having an
Calestani, Cristina +2 more
core +1 more source