Results 1 to 10 of about 27,304 (237)

Considerations Regarding the Cytotoxicity of Certain Classes of Fungal Polyketides—Potential Raw Materials for Skincare Products for Healthy and Diseased Skin [PDF]

Pharmaceutics
Background: This study investigates the cytotoxicity of microbial polyketides biosynthesized by Monascus species through both in silico and in vitro approaches.
Daniela Albisoru, Nicoleta Radu, Raluca Senin, Mihai Dan Caramihai, Mihaela Begea, Oksana Mulesa, Viviana Roman, Marinela Bostan   +7 more
doaj   +2 more sources

New Polyketides and a Ferroptosis Inhibitor from the Marine-Derived Fungus Diaporthe searlei CS-HF-1 [PDF]

Marine Drugs
As a driver of neurodegenerative disorders, ischemic injuries, and acute organ dysfunction, ferroptosis represents a therapeutic target, and its inhibition may provide novel therapies. In our ongoing efforts to discover ferroptosis inhibitors from fungal
Jicheng Xiao, Peng Wu, Yan Zhang, Qi Lv, Yulang Chi, Wei Xu, Wenzhen Lin, Zhongbin Cheng   +7 more
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Polyketides [PDF]

Heterocycles, 2007
I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
  +5 more sources

Natural Polyketides Act as Promising Antifungal Agents

Biomolecules, 2023
Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability.
Li Wang, Hui Lu, Yuanying Jiang
doaj   +1 more source

The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones

Molecules, 2023
The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents ...
José X. Soares, Inês Afonso, Adaleta Omerbasic, Daniela R. P. Loureiro, Madalena M. M. Pinto, Carlos M. M. Afonso   +5 more
doaj   +1 more source

Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases

Microbial Cell Factories, 2020
Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure.
Jia Wang, Ruihua Zhang, Xin Chen, Xinxiao Sun, Yajun Yan, Xiaolin Shen, Qipeng Yuan   +6 more
doaj   +1 more source

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Nature Communications, 2021
Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of ...
Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel, Marnix H. Medema   +10 more
doaj   +1 more source

ENGINEERING MICROBES FOR PLANT POLYKETIDE BIOSYNTHESIS

Computational and Structural Biotechnology Journal, 2012
Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries.
François-Xavier Lussier, David Colatriano, Zach Wiltshire, Jonathan E. Page, Vincent J.J. Martin   +4 more
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Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

Nature Communications, 2021
Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal moiety
Britta Frensch, Thorsten Lechtenberg, Michel Kather, Zeynep Yunt, Martin Betschart, Bernd Kammerer, Steffen Lüdeke, Michael Müller, Jörn Piel, Robin Teufel   +9 more
doaj   +1 more source

Animal biosynthesis of complex polyketides in a photosynthetic partnership

Nature Communications, 2020
Complex polyketides are usually produced by microbes, whereas the origin of polyketides found in animals remained unknown. This study shows that sacoglossan animals, such as sea slugs, employ fatty acid synthase-like proteins to produce microbe-like ...
Joshua P. Torres, Zhenjian Lin, Jaclyn M. Winter, Patrick J. Krug, Eric W. Schmidt   +4 more
doaj   +1 more source