Results 101 to 110 of about 27,304 (237)

De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis. [PDF]

open access: yes, 2015
BackgroundBixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L.
Aguilar-Espinosa, Margarita   +5 more
core   +3 more sources

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Total synthesis of elansolids B1 and B2

open access: yesBeilstein Journal of Organic Chemistry, 2017
The elansolids A1–A3, B1, and B2 are secondary metabolites formed by the gliding bacterium Chitinophaga sancti. They show antibacterial activity against Gram-positive bacteria.
Liang-Liang Wang, Andreas Kirschning
doaj   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian   +2 more
wiley   +1 more source

Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

open access: yesBeilstein Journal of Organic Chemistry, 2014
Four new polyketides have been identified in culture filtrates of the fungal strain Penicillium sp. IBWF104-06 isolated from a soil sample. They are structurally based on the same trans-decalinpentanoic acid skeleton as tanzawaic acids A–H.
Louis P. Sandjo   +3 more
doaj   +1 more source

The evolution of genome mining in microbes – a review [PDF]

open access: yes, 2016
This article reviews the development of genome mining strategies in bacteria during the last decade.
Alanjary, Mohammad   +2 more
core   +1 more source

Convergence and parallelism in the evolution of plant metabolism

open access: yesJournal of Integrative Plant Biology, EarlyView.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa   +4 more
wiley   +1 more source

From DNA Sequences to Chemical Structures – Methods for Mining Microbial Genomic and Metagenomic Data Sets for New Natural Products

open access: yesFood Technology and Biotechnology, 2010
Rapid mining of large genomic and metagenomic data sets for modular polyketide synthases, non-ribosomal peptide synthetases and hybrid polyketide synthase/non-ribosomal peptide synthetase biosynthetic gene clusters has been achieved using the generic ...
Jurica Zucko   +7 more
doaj  

Biosynthesis of Akaeolide and Lorneic Acids and Annotation of Type I Polyketide Synthase Gene Clusters in the Genome of Streptomyces sp. NPS554

open access: yesMarine Drugs, 2015
The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors.
Tao Zhou   +5 more
doaj   +1 more source

David Hopwood and the emergence of Streptomyce genetics [PDF]

open access: yes, 2010
Streptomyces spp. are unusual among bacteria in growing as mycelial colonies with sporulating aerial hyphae. They are very important as the source of most of the major antibiotics.
Keith Chater
core   +2 more sources

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