Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening [PDF]
, 2003 New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a macroarray cDNA library. The comparison was performed between mRNA populations of embryos having an
Calestani, Cristina +2 more
core +1 more source
MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]
, 2012 Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag +59 more
core +6 more sources
Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]
Applied Microbiology and Biotechnology, 2015 Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
openaire +2 more sources
Simultaneous Effect of Temperature and Irradiance on Growth and Okadaic Acid Production from the Marine Dinoflagellate Prorocentrum belizeanum [PDF]
, 2014 Benthic marine dioflagellate microalgae belonging to the genus Prorocentrum are a major source of okadaic acid (OA), OA analogues and polyketides. However, dinoflagellates produce these valuable toxins and bioactives in tiny quantities, and they grow ...
Belarbi, El Hassan +6 more
core +3 more sources
Sampling Terrestrial Environments for Bacterial Polyketides
Molecules, 2017 Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest.
Patrick Hill +2 more
doaj +1 more source
Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]
, 2012 Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T. +4 more
core +2 more sources
Draft Genome Sequence of Streptomyces phaeoluteigriseus DSM41896 [PDF]
, 2017 The draft genome for the type strain Streptomyces phaeoluteigriseus DSM41896 (ISP 5182) is reported. It was classified as a member of the Streptomyces violaceusniger clade; however, a polyphasic study showed it was a separate species based on its ...
Aziz +10 more
core +1 more source
Marine Drugs, 2022 Four new polyketide compounds, including two new unique isocoumarins penicillol A (1) and penicillol B (2) featuring with spiroketal rings, two new citreoviridin derivatives citreoviridin H (3) and citreoviridin I (4), along with four known analogues ...
Chen Chen +6 more
doaj +1 more source
Recently Discovered Secondary Metabolites from Streptomyces Species
Molecules, 2022 The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all
Heather J. Lacey, Peter J. Rutledge
doaj +1 more source
Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes
Angewandte Chemie, EarlyView.Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara +4 more
wiley +2 more sources