Results 31 to 40 of about 27,304 (237)

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

Chemical Communications, 2020
Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo, Soligot, Claire, Weissman, Kira J., Jacob, Christophe   +3 more
openaire   +4 more sources

Microbial communities and bioactive compounds in marine sponges of the family Irciniidae-a review [PDF]

, 2014
Marine sponges harbour complex microbial communities of ecological and biotechnological importance. Here, we propose the application of the widespread sponge family Irciniidae as an appropriate model in microbiology and biochemistry research. Half a gram
Anand, Asano, Bandara, Bayer, Bringmann, Brochier-Armanet, Cardoso, Cook, Cook, Cristiane Hardoim, De Caralt, De Rosa, De Rosa, De Rosa, De Rosa, De Voogd, Degrassi, di Camillo, Dieckmann, Dobretsov, Duckworth, Duckworth, Enticknap, Ereskovsky, Erwin, Erwin, Erwin, Esteves, Fan, Fan, Fieseler, Fiore, Fisch, Flemer, Friedrich, Gaino, Han, Hardoim, Hardoim, Hardoim, Hentschel, Hentschel, Hentschel, Hentschel, Hochmuth, Hoffmann, Hoffmann, Holden, Höller, Isaacs, Jaeckle, Kalia, Kalinovskaya, Kamke, Kamke, Lee, Lee, Lee, Li, Lindquist, Liu, Lopanik, Lopanik, Lopanik, Lopanik, Love, Luter, Maldonado, Man-Aharonovich, Mohamed, Mohamed, Mohamed, Mohamed, Mohamed, Muscholl-Silberhorn, Osinga, O’Halloran, Pantile, Paz, Pester, Piel, Piel, Pita, Pita, Pita, Prokof'eva, Rinkevich, Rodrigo Costa, Sara, Schirmer, Schmitt, Schmitt, Schmitt, Sharp, Siegl, Siegl, Simister, Simister, Simister, Skindersoe, Spalding, Spang, Stabili, Staunton, Sudek, Tabares, Taylor, Taylor, Thakur, Thakur, Thiel, Thomas, Thomas, Usher, Usher, Vacelet, Van Soest, Van Treeck, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Weisz, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Wulff, Wörheide, Yang, Zan, Zehr, Zehr   +136 more
core   +2 more sources

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

The Genetic Basis of Toxin Biosynthesis in Dinoflagellates

Microorganisms, 2019
In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth rates. One factor that may play a role in their ecological success is the production of complex secondary metabolite ...
Arjun Verma, Abanti Barua, Rendy Ruvindy, Henna Savela, Penelope A. Ajani, Shauna A. Murray   +5 more
doaj   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source

Engineering Polyketide Synthases [PDF]

The Scientific World JOURNAL, 2002
Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
openaire   +3 more sources

Characterization of Eight Novel Spiroleptosphols from Fusarium avenaceum

Molecules, 2019
Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U−Z (1−8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR ...
Klaus Ringsborg Westphal, Manuela Ilse Helga Werner, Katrine Amalie Hamborg Nielsen, Jens Laurids Sørensen, Valery Andrushchenko, Jacob Winde, Morten Hertz, Mikkel Astrup Jensen, Mathilde Lauge Mortensen, Petr Bouř, Teis Esben Sondergaard, Reinhard Wimmer   +11 more
doaj   +1 more source

Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a "One Health" Approach. [PDF]

, 2019
Treating infection is a key part of the work of most clinicians [...]
Lipman, J, Lonsdale, DO
core   +1 more source

The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation

Nature Communications, 2017
Polyketides are secondary metabolites mainly found in aerobic organisms with wide applications in medicine and agriculture. Here, the authors uncover new polyketides native to the anaerobic bacterium Clostridium acetobutylicum and show their role in ...
Nicolaus A. Herman, Seong Jong Kim, Jeffrey S. Li, Wenlong Cai, Hiroyuki Koshino, Wenjun Zhang   +5 more
doaj   +1 more source

Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae [PDF]

, 2013
BACKGROUND: Fungal polyketides include commercially important pharmaceuticals and food additives, e.g. the cholesterol-lowering statins and the red and orange monascus pigments.
Frandsen, Rasmus John Normand, Mortensen, Uffe Hasbro, Naesby, Michael, Rugbjerg, Peter   +3 more
core   +1 more source