Results 41 to 50 of about 27,304 (237)

Total synthesis of decarboxyaltenusin

Beilstein Journal of Organic Chemistry, 2021
The total synthesis of decarboxyaltenusin (5’-methoxy-6-methyl-[1,1’-biphenyl]-3,3’,4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene ...
Lucas Warmuth, Aaron Weiß, Marco Reinhardt, Anna Meschkov, Ute Schepers, Joachim Podlech   +5 more
doaj   +1 more source

Chemical probes for the functionalization of polyketide intermediates [PDF]

, 2014
A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S.
Abdulla, Adovelande, Bhatt, Böhrsch, Carter, Cortes, Cummings, Dutta, Goss, Grammel, Gupta, Huczynski, Hüttel, Kirschning, Knobloch, Koryakina, Kushnir, Laureti, Lyazghi, Newman, Ojima, Oliynyk, Purser, Rostovtsev, Rowe, Schilling, Schmidt, Schmidt, Serwa, Sletten, Sundermann, Tosin, Tosin, Tosin, Tosin, Walker, Walker, Wang, Weissman, Whicher, Winter   +40 more
core   +2 more sources

Synthesis of the polyketide section of seragamide A and related cyclodepsipeptides via Negishi cross coupling

Beilstein Journal of Organic Chemistry, 2019
The synthesis of the polyketide section present in the potently cytotoxic marine cyclodepsipeptide jasplakinolide and related natural products, geodiamolides and seragamides, is reported.
Jan Hendrik Lang, Thomas Lindel
doaj   +1 more source

Steroidi i poliketidi iz kore biljke Uvaria hamiltonii [PDF]

, 2004
Two known steroids, stigmasterol and 6beta-hydroxystigmasta-4,22-dien-3-one (1) and two unusual polyketides, cis-4-hydroxymellein (2) and trans-4-hydroxymellein (3) were isolated from the stem bark of Uvaria hamiltonii.
CHOUDHURY M. HASAN, KAMRUN NAHAR ASHA, MOHAMMAD A. RASHID, RASHEDUZZAMAN CHOWDHURY   +3 more
core   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of C-13 chemical shifts [PDF]

, 2013
In this paper the stereostructural investigation of two new oxygenated polyketides, plakilactones G and H, isolated from the marine sponge Plakinastrella mamillaris collected at Fiji Islands, is reported.
Bifulco, Giuseppe, Butts, Craig P., D'Auria, Maria Valeria, De Marino, Simona, Di Micco, Simone, Festa, Carmen, Riccio, Raffaele, Zampella, Angela   +7 more
core   +6 more sources

Biocontrol potential of Bacillus velezensis EM-1 associated with suppressive rhizosphere soil microbes against tobacco bacterial wilt

Frontiers in Microbiology, 2022
Tobacco bacterial wilt caused by Ralstonia solanacearum is one of the most devastating diseases. Microbial keystone taxa were proposed as promising targets in plant disease control.
Xiaona Sui, Xiaobin Han, Jianmin Cao, Yiqiang Li, Yuan Yuan, Jianyu Gou, Yanfen Zheng, Chen Meng, Chengsheng Zhang   +8 more
doaj   +1 more source

Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides [PDF]

, 2008
In this paper we characterize the metabolic fingerprint and first reported anti-inflammatory activity of Hypericum gentianoides. H. gentianoides has a history of medical use by Native Americans, but it has been studied very little for biological activity.
Birt, Diane, Birt, Diane, Hammer, Kimberly, Hillwig, Matthew, Wurtele, Eve, Wurtele, Eve   +5 more
core   +3 more sources

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source