Results 51 to 60 of about 27,304 (237)

Expression, purification, and crystallization of a plant polyketide cyclase from Cannabis sativa [PDF]

, 2015
Plant polyketides are a structurally diverse family of natural products. In the biosynthesis of plant polyketides, the construction of the carbocyclic scaffolds is a key step for diversifying the polyketide structure.
Abdel-Rahman, Abe, Abe, Adams, Austin, Bingman, Cornilescu, Dgany, Gagne, Kabsch, Lytle, Marín, McCoy, Sciara, Taura, Thompson, Vagin   +16 more
core   +2 more sources

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity

Marine Drugs, 2016
Four new polyketides: nectriacids A–C (1–3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), and macrocarpon C (7) were isolated from the culture of the endophytic fungus Nectria sp ...
Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Senhua Chen, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang, Zhigang She   +9 more
doaj   +1 more source

Polyketide synthesis in vitro on a modular polyketide synthase

Chemistry & Biology, 1995
The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H., Cortés, Jesus, Brown, Murray J.B., Cutter, Annabel L., Staunton, James, Leadlay, Peter F.   +5 more
openaire   +2 more sources

Polyketides from Plakortis Sponges around Caribbean Coastal Regions: Collection, Isolation, Characterization, and Bioactivity

Coasts
The coastal region of the Caribbean is notable for the chemical diversity found in its sponge products, resulting in the biosynthesis of a range of natural marine products, including polyketides.
Raúl R. Rodríguez-Berríos, Jeremy A. Rodríguez-Vargas, Francisco Colón-Cartagena, Ulises Maldonado-Silva, Yermarie W. Ortiz-Colón, Alejandro Escalante-Castaneda, Arianthony Conde-González, Keiry Y. Álamo-Diverse   +7 more
doaj   +1 more source

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

Metabolites, 2020
The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites.
Najla Ali Alburae, Afrah E. Mohammed, Hajer Saeed Alorfi, Adnan Jaman Turki, Hani Zakaria Asfour, Walied Mohamed Alarif, Ahmed Abdel-Lateff   +6 more
doaj   +1 more source

Fungi - an Amalgam of Toxins and Antibiotics: a Mini- Review [PDF]

, 2020
Fungi are eukaryotes with many functions. Earlier, fungi were classified in the plant kingdom but were later classified as a separate kingdom due to their unique cell walls. Fungi are heterotrophs like animals and are more closely related to animals. The
Ahmed, M. (Muddassir), Basirat, U. (Usama), Butt, F. (Farooq), Muddassir, M. (Maria)   +3 more
core  

Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology

mSystems, 2017
Bacteria possess an amazing capacity to synthesize a diverse range of structurally complex, bioactive natural products known as specialized (or secondary) metabolites.
Kirk J. Grubbs, Rachel M. Bleich, Kevin C. Santa Maria, Scott E. Allen, Sherif Farag, Elizabeth A. Shank, Albert A. Bowers   +6 more
doaj   +1 more source

Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome

mSystems, 2020
Polyketides (PKs) and nonribosomal peptides (NRPs) are two microbial secondary metabolite (SM) families known for their variety of functions, including antimicrobials, siderophores, and others.
Barak Dror, Zongqiang Wang, Sean F. Brady, Edouard Jurkevitch, Eddie Cytryn   +4 more
doaj   +1 more source

Genomic blueprints of sponge-prokaryote symbiosis are shared by low abundant and cultivatable Alphaproteobacteria [PDF]

, 2019
Marine sponges are early-branching, filter-feeding metazoans that usually host complex microbiomes comprised of several, currently uncultivatable symbiotic lineages.
Cox, Cymon, da Rocha, Ulisses N, da Silva Costa, Rodrigo, Hentschel, Ute, Karimi, Elham, Keller-Costa, Tina, Slaby, Beate M   +6 more
core   +4 more sources