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Polymerase Chain Reaction: Expedition of a ubiquitous tool

open access: yesSRM Journal of Research in Dental Sciences, 2011
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The polymerase chain reaction

Trends in Genetics, 1989
The polymerase chain reaction (PCR) is a powerful new method for 'in vitro cloning'. It can selectively amplify a single molecule of template DNA several millionfold in a few hours and has made possible new approaches to problems in molecular genetics, evolutionary biology, and development.
T J, White, N, Arnheim, H A, Erlich
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The Polymerase Chain Reaction

Current Protocols in Protein Science, 2002
AbstractThis appendix describes the methodology behind PCR and gives a method for amplifying DNA enzymatically by the PCR and for optimizing this reaction for the sequence and primer set of interest.
Martha F, Kramer, Donald M, Coen
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Polymerase Chain Reaction

Journal of Infectious Diseases, 1988
organism number to readily detectable levels, yet culture is not always easy or successful. A novel technique, the polymerase chain reaction (PCR), was recently developed for in vitro amplification of the DNA or RNA of an organism or gene defect, and culture may not be required.
G, Schochetman, C Y, Ou, W K, Jones
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Modeling the Polymerase Chain Reaction

Journal of Computational Biology, 1995
We introduce a mathematical model to treat the polymerase chain reaction (PCR), where we regard the accumulation of new molecules during a PCR cycle as a randomly bifurcating tree. This model enables us to compute an approximate formula for the distribution of the number of replications that have occurred between a pair of molecules, which depends on ...
Gunter Weiss, Arndt von Haeseler
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