Click Chemistry in Polymersome Technology [PDF]
PharmaceuticalsPolymersomes, self-assembled nanoparticles composed of amphiphilic block copolymers, have emerged as promising versatile nanovesicles with various applications, such as drug delivery, medical imaging, and diagnostics.
Nuno M. Saraiva +3 more
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Hallmarks of Polymersome Characterization [PDF]
ACS Materials AuPolymersomes have the potential to become the next generation of vesicular drug delivery systems. Their high chemical versatility and in certain cases higher membrane stability than liposomes raised the high hopes for polymersomes as a drug carrier, but the clinical translation has been slow.
Simon Matoori
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Polymersome-based nanomedicine for combined cancer therapy [PDF]
Drug DeliveryCancer is a complex disease characterized by uncontrolled cell growth and spread, often resulting in metastasis. The use of combination therapy, which involves the simultaneous application of two or more treatment methods, aims to enhance effectiveness ...
Aidin Mohammadi Zonouz +7 more
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Metformin-loaded J-AuPPS for infected diabetic wound treatment [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionInfected diabetic wounds pose a significant clinical challenge owing to the complex wound microenvironment. Various multifunctional synergistic therapeutic nanomaterials have been successfully developed to treat diabetic infected wounds ...
Fuli Yin +5 more
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ENT‐1‐Targeted Polymersomes to Enhance the Efficacy of Methotrexate in Choriocarcinoma Treatment [PDF]
Small ScienceGestational choriocarcinoma (CC) is a rare and highly malignant cancer originating from the trophoblastic layers of the placenta. Currently, methotrexate (MTX) is the first‐line treatment for CC; however, due to the aggressive and metastatic nature of CC,
Babak Mamnoon +10 more
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Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis [PDF]
Bioactive MaterialsThe treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels are developed by incorporating gallic acid and ...
Huan He +7 more
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Polymersomes as Innovative, Stimuli-Responsive Platforms for Cancer Therapy [PDF]
PharmaceuticsThis review addresses the urgent need for more targeted and less toxic cancer treatments by exploring the potential of multi-responsive polymersomes. These advanced nanocarriers are engineered to deliver drugs precisely to tumor sites by responding to ...
Irina Negut, Bogdan Bita
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Tunable Intranasal Polymersome Nanocarriers Triggered Olanzapine Brain Delivery and Improved In Vivo Antipsychotic Activity [PDF]
PharmaceuticsBackground: Olanzapine (Ola) is a second-generation antipsychotic with clinical utility limited by poor brain bioavailability due to blood–brain barrier restriction, hepatic first-pass metabolism, and systemic side effects.
Ahmed A. Katamesh +9 more
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Morphological Diversity in Diblock Copolymer Solutions: A Molecular Dynamics Study
Colloids and Interfaces, 2023 Coarse-grained molecular dynamics simulations that incorporate explicit water-mediated hydrophilic/hydrophobic interactions are employed to track spatiotemporal evolution of diblock copolymer aggregation in initially homogeneous solutions.
Senyuan Liu, Radhakrishna Sureshkumar
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Dynamic metastable polymersomes enable continuous flow manufacturing
Nature Communications, 2023 Polymersomes are polymeric analogues of liposomes with exceptional physical and chemical properties. Despite being dubbed as next-generation vesicles since their inception nearly three decades ago, polymersomes have yet to experience translation into the
Chin Ken Wong +2 more
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