Results 11 to 20 of about 3,055 (192)
Polymersomes in “Gelly” Polymersomes: Toward Structural Cell Mimicry [PDF]
Langmuir, 2011 We demonstrate here the formation of compartmentalized polymersomes with an internal "gelly" cavity using an original and versatile process. Nanosize polymersomes of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA), formed by a solvent displacement method are encapsulated with a rough "cytoplasm mimic" in giant polymersomes of poly ...
Maïté Marguet +2 more
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Bio-Inspired Polymersome Nanoreactors [PDF]
CHIMIA, 2019 : Two key concepts in living organisms are that biochemical reactions are sequestered into reaction compartments such as cells and organelles, and that many of the complex biological reaction cascades involve transient activation of reactions in response
Omar Rifaie-Graham +2 more
doaj +5 more sources
Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery
Nanomaterials, 2022 Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and ...
Elisa Hernández Becerra +3 more
doaj +2 more sources
Metabolically Active, Fully Hydrolysable Polymersomes [PDF]
Angewandte Chemie International Edition, 2019 AbstractThe synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile).
Yunqing Zhu +6 more
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Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions [PDF]
Nature Communications, 2017 Polymersomes have become a powerful tool in drug delivery and synthetic biology, but their use can be restricted by a lack of versatile methods for shape control. Here the authors demonstrate access to a range of non-spherical polymersome morphologies by
Chin Ken Wong +3 more
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Regulating vesicle bilayer permeability and selectivity via stimuli-triggered polymersome-to-PICsome transition [PDF]
Nature Communications, 2020 Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion complex vesicles created using a stimuli-triggered transition from polymersomes and show high ...
Xiaorui Wang +3 more
doaj +2 more sources
Redox-Responsive Polymersomes as Smart Doxorubicin Delivery Systems
Pharmaceutics, 2022 Stimuli-responsive polymersomes have emerged as smart drug delivery systems for programmed release of highly cytotoxic anticancer agents such as doxorubicin hydrochloride (Dox·HCl).
Carmen Ferrero +2 more
doaj +1 more source
Charge-Complementary Polymersomes for Enhanced mRNA Delivery
Pharmaceutics, 2023 Messenger RNA (mRNA) therapies have emerged as potent and personalized alternatives to conventional DNA-based therapies. However, their therapeutic potential is frequently constrained by their molecular instability, susceptibility to degradation, and ...
HakSeon Kim +5 more
doaj +1 more source
Development of Polymersomes Co-Delivering Doxorubicin and Melittin to Overcome Multidrug Resistance
Molecules, 2023 Multidrug resistance (MDR) is one of the major barriers in chemotherapy. It is often related to the overexpression of efflux receptors such as P-glycoprotein (P-gp).
Eunkyung Han +5 more
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Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication. [PDF]
ChemistryThis review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Saorin G, Huang X, Mihali V, Palivan CG.
europepmc +2 more sources