Results 41 to 50 of about 3,285 (181)

Polymersome Shape Transformation at the Nanoscale [PDF]

ACS Nano, 2013
Polymer vesicles, also named polymersomes, are valuable candidates for drug delivery and micro- or nanoreactor applications. As far as drug delivery is concerned, the shape of the carrier is believed to have a strong influence on the biodistribution and cell internalization.
Salva, Romain, Le Meins, Jean-François, Sandre, Olivier, Brûlet, Annie, Schmutz, Marc, Guenoun, Patrick, Lecommandoux, Sébastien   +6 more
openaire   +3 more sources

Probing and Tuning the Permeability of Polymersomes [PDF]

ACS Central Science, 2020
Polymersomes are a class of synthetic vesicles composed of a polymer membrane surrounding an aqueous inner cavity. In addition to their overall size, the thickness and composition of polymersome membranes determine the range of potential applications in which they can be employed.
Alisha J. Miller, Amanda K. Pearce, Jeffrey C. Foster, Rachel K. O’Reilly   +3 more
openaire   +3 more sources

Photopolymerization-Induced Polymersome Rupture [PDF]

Langmuir, 2019
Poly(butadiene)- b-poly(ethylene oxide) (PBut2.5- b-PEO1.3) giant polymersomes were prepared using an emulsion-centrifugation method. The impact of a fast decrease of the osmotic pressure inside the lumen of giant PBut- b-PEO vesicles was studied by confocal microscopy. This osmotic imbalance was created by performing the photoinduced polymerization of
Sophie C. Larnaudie, Ariane Peyret, Louis Beauté, Pierre Nassoy, Sébastien Lecommandoux   +4 more
openaire   +2 more sources

Liposome mimicking polymersomes; A comparative study of the merits of polymersomes in terms of formulation and stability

International Journal of Pharmaceutics: X, 2020
The past few decades have seen a significant rise in research into alternative polymer based nanosized unilamellar drug delivery systems, termed polymersomes.
Noorjahan Aibani, Talat N. Khan, Bridgeen Callan   +2 more
doaj   +1 more source

Dually Responsive Poly(N-vinylcaprolactam)-b-poly(dimethylsiloxane)-b-poly(N-vinylcaprolactam) Polymersomes for Controlled Delivery

Molecules, 2022
Limited tissue selectivity and targeting of anticancer therapeutics in systemic administration can produce harmful side effects in the body. Various polymer nano-vehicles have been developed to encapsulate therapeutics and prevent premature drug release.
Veronika Kozlovskaya, Yiming Yang, Fei Liu, Kevin Ingle, Aftab Ahmad, Ganesh V. Halade, Eugenia Kharlampieva   +6 more
doaj   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Multi‐Responsive Bowl‐Shaped Janus Nanomotors Based on Polyitaconic acid/Polypyrrole on the Surface of Iron Oxide Nanoparticles with Chemical, Electrical, and Magnetic Field Actuation for Targeted Drug Delivery Applications

Advanced NanoBiomed Research, EarlyView.
Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi, Sepideh Khoee, Shima Tavakoli, Oommen P. Varghese   +3 more
wiley   +1 more source

Modular Approach to the Functionalization of Polymersomes [PDF]

Biomacromolecules, 2020
Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly.
Sjoerd J. Rijpkema, Sabine G. H. A. Langens, Marnix R. van der Kolk, Katerina Gavriel, B. Jelle Toebes, Daniela A. Wilson   +5 more
openaire   +3 more sources

Dewetting‐Assisted Interface Templating: Complex Emulsions to Multicavity Particles

Advanced Science, 2022
Interfacial tension‐driven formation of intricate microparticle geometries from complex emulsions is presented in this work. Emulsion‐templating is a reliable platform for the generation of a diverse set of microparticles. Here, water‐in‐styrene‐in‐water
Naresh Yandrapalli, Markus Antonietti
doaj   +1 more source

Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi, Shogo Yoshimoto, Katsutoshi Hori   +2 more
wiley   +1 more source